Validation and scopolamine-reversal of latent learning in the water maze utilizing a revised direct platform placement procedure

Malin, David H.; Schaar, Krystal L.; Izygon, Jonathan; Nghiem, Duyen M.; Jabitta, Sikirat Yewande; Henceroth, Mallori M.; Chang, Yu‐Hsuan; Daggett, Jenny M.; Ward, Christopher P.

doi:10.1016/j.pbb.2015.05.015

Cited by 4 publications

(2 citation statements)

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“…Learning and memory ability for evaluating cognitive function were determined using Morris water maze assay according to previous method . Briefly, a circular stainless‐steel pool was divided into four quadrants.…”

Section: Methodsmentioning

confidence: 99%

Comparative Analyses of DHA‐Phosphatidylcholine Forage and Liposomes on Alzheimer's Disease in SAMP8 Mice

Meng

Zhou

Xue

et al. 2019

Euro J Lipid Sci & Tech

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The present work comparatively evaluates the efficacy of docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome on Alzheimer's disease (AD) in the senescence‐accelerated prone 8 (SAMP8) mice and illustrates the potential mechanism. The dose of DHA‐PC in forage group (1% of total diets) is equal to that of liposome group. The results of Morris maze test show that both DHA‐PC forage and liposome obviously alleviated cognitive impairment (P < 0.05). Moreover, the administration of DHA‐PC liposome shows advantage than forage in reducing β‐amyloid (Aβ) accumulation (P < 0.05). Meanwhile, DHA‐PC forage exhibits excellent inhibition on the IL‐1β protein expression (P < 0.05) and improvement in the protein levels of SYN and BDNF (P < 0.05). These data are the first to perform comparative analysis of DHA‐PC forage and liposome on AD. Practical Applications: The outcomes in the present study might help to understand the bioactivities of DHA‐PC forage and liposomes, which might exert potential application value for dietary supplement with neuroprotective effects. Both docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome shows benefits in alleviating Alzheimer's disease development in senescence‐accelerated prone 8 mice by inhibiting β‐amyloid generation, oxidative stress, apoptosis, neural inflammation, and enhancing neurotrophins pathway in different degrees.

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Section: Methodsmentioning

confidence: 99%

Comparative Analyses of DHA‐Phosphatidylcholine Forage and Liposomes on Alzheimer's Disease in SAMP8 Mice

Meng

Zhou

Xue

et al. 2019

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

show abstract

“…The Morris water maze test, a common behavioral test for evaluating cognitive function, was carried out 2 days after Barnes maze test. The two‐way repeated‐measures ANOVA results [18.17 (3), 0.000] showed that during the navigation test, the latency of SAMP8 group was significantly increased compared to that of SAMR1 group ( p = 0.000); no significance was found between EPA‐PC/PE and EPA‐PS groups ( p = 0.259), while the p ‐value of EPA‐PC/PE versus SAMP8 was 0.002 and EPA‐PS versus SAMP8 was 0.000.…”

Section: Resultsmentioning

confidence: 99%