Validation of a client‐based clinical metrology instrument for the evaluation of canine elbow osteoarthritis

Hercock, Carol Ann; Pinchbeck, Gina; Giejda, A; Clegg, Peter; Innes, John F.

doi:10.1111/j.1748-5827.2009.00765.x

Cited by 118 publications

(157 citation statements)

References 27 publications

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“…In the present study, we used more restrictive selection criteria to minimize variation in the study population. There is evidence to suggest that OA of joints other than the hip in dogs, such as the elbow, may be more refractory to medical treatment [19]. Additionally, stifle OA in dogs is often associated with joint instability from cruciate rupture, which our clinical experience suggests is also more refractory to medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis

et al. 2012

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BackgroundPain and impaired mobility because of osteoarthritis (OA) is common in dogs and humans. Efficacy studies of analgesic drug treatment of dogs with naturally occurring OA may be challenging, as a caregiver placebo effect is typically evident. However, little is known about effect sizes of common outcome-measures in canine clinical trials evaluating treatment of OA pain. Forty-nine client-owned dogs with hip OA were enrolled in a randomized, double-blinded placebo-controlled prospective trial. After a 1 week baseline period, dogs were randomly assigned to a treatment (ABT-116 – transient receptor potential vanilloid 1 (TRPV1) antagonist, Carprofen – non-steroidal anti-inflammatory drug (NSAID), Tramadol - synthetic opiate, or Placebo) for 2 weeks. Outcome-measures included physical examination parameters, owner questionnaire, activity monitoring, gait analysis, and use of rescue medication.ResultsAcute hyperthermia developed after ABT-116 treatment (P < 0.001). Treatment with carprofen (P ≤ 0.01) and tramadol (P ≤ 0.001) led to improved mobility assessed by owner questionnaire. Nighttime activity was increased after ABT-116 treatment (P = 0.01). Kinetic gait analysis did not reveal significant treatment effects. Use of rescue treatment decreased with treatment in the ABT-116 and Carprofen groups (P < 0.001). Questionnaire score and activity count at the end of treatment were correlated with age, clinical severity at trial entry, and outcome measure baseline status (SR ≥ ±0.40, P ≤ 0.005). Placebo treatment effects were evident with all variables studied.ConclusionTreatment of hip OA in client-owned dogs is associated with a placebo effect for all variables that are commonly used for efficacy studies of analgesic drugs. This likely reflects caregiver bias or the phenomenon of regression to the mean. In the present study, outcome measures with significant effects also varied between groups, highlighting the value of using multiple outcome measures, as well as an a priori analysis of effect size associated with each measure. Effect size data from the present study could be used to inform design of future trials studying analgesic treatment of canine OA. Our results suggest that analgesic treatment with ABT-116 is not as effective as carprofen or tramadol for treatment of hip arthritis pain in client-owned dogs.

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Section: Discussionmentioning

confidence: 99%

Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis

et al. 2012

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“…The use of questionnaires derives from human medicine and aims to evaluate patients presenting with joint disease [1,4,10,19,24]. Questionnaires represent an effective and rapid detection method that is also easy to administer on a large-scale, although it requires the cooperation of the patient (human medicine) or owner (veterinary medicine) [25].…”

Section: Discussionmentioning

confidence: 99%

Biceps femoris muscle transposition for treatment of cranial cruciate ligament rupture in small breed dogs

et al. 2012

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The purpose of this study was to evaluate a new extracapsular surgical technique for the treatment of cranial cruciate ligament rupture in small breed dogs. Nine small breed dogs (seven females and two males) weighing ≤ 15 kg were treated with biceps femoris muscle transposition (BFT). The duration of the BFT procedure was 20 min. Each patient underwent a standard clinical protocol and a questionnaire for the owners. Follow-up (at 1, 3, and 12 months postoperative) confirmed significant improvement in all patients, especially at 1 month postoperatively (p < 0.01) and again after complete stifle joint assessment at 3 months postoperatively. After 12 months, only two patients showed a slight increase in osteoarthritis. According to our results, BFT is a simple extracapsular surgical technique that can be used for the treatment of cranial cruciate ligament rupture in small breed dogs.

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“…A blood sample was collected for routine health screening and orthogonal view radiographs of the index joint were examined. Owners completed three CMIs: the Liverpool Osteoarthritis in Dogs (LOAD) (Hercock and others 2009, Walton and others 2013), the Canine Brief Pain Inventory (CBPI) (Brown and others 2007) and the Helsinki Chronic Pain Index (HCPI) (Hielm-Bjorkman and others 2009). …”

Section: Methodsmentioning

confidence: 99%

Mavacoxib and meloxicam for canine osteoarthritis: a randomised clinical comparator trial

et al. 2014

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NSAIDs are the cornerstone of medical management of canine osteoarthritis (OA). Meloxicam is a daily-administered NSAID widely available in a liquid formulation and manufacturer's summary of product characteristics (SPC) advise that it is given at the lowest effective dose. Mavacoxib is a long-acting NSAID given as a monthly tablet. This study compares these drugs in the management of canine OA. In all, 111 dogs with OA of the elbow, hip or stifle were randomly assigned to receive one of these NSAIDs for a 12-week period, and to administer them as per the manufacturer's SPC. Outcomes, including ground reaction forces and three validated clinical metrology instruments, were measured at baseline, 6 and 12 weeks. Improvements were seen in all outcome measures for both groups to a similar degree, and adverse events occurred at a similar rate. There were significant improvements in outcome measures from week 6 to week 12, as well as from baseline. Long-term meloxicam dose was more important than recent dose. Clinical efficacy and adverse event rates are similar for meloxicam and mavacoxib when administered as per their UK SPC. This is relevant information for veterinary surgeons when prescribing NSAID treatment for canine OA.

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Validation of a client‐based clinical metrology instrument for the evaluation of canine elbow osteoarthritis

Cited by 118 publications

References 27 publications

Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis

Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis

Biceps femoris muscle transposition for treatment of cranial cruciate ligament rupture in small breed dogs

Mavacoxib and meloxicam for canine osteoarthritis: a randomised clinical comparator trial

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