It is conventional to assume that the role of the soil-structure interaction (SSI) is beneficial to the buildings under seismic loading. However, lessons learned from recent earthquakes revealed that this assumption could be misleading, and SSI may have different effects on the seismic response of different structural systems. In this study, an enhanced soil-structure numerical model is developed and verified using ABAQUS software to assess the impact of SSI on high-rise frame-core tube structures. The seismic responses of 20, 30, and 40-storey buildings constructed on soil class Ee (according to Australian Standards) under four earthquake acceleration records have been studied. The results in terms of maximum lateral deflections, foundation rocking, inter-storey drifts and storey shear forces for the rigid base and flexible base frame-core tube structures have been discussed and compared.Generally, SSI has a remarkable impact on the seismic behaviour of high-rise frame-core tube structures since it can increase the lateral deflections and inter-storey drifts and decrease storey shear forces of structures. However, It is worth noting that the seismic responses of soil-structure systems under near and far field earthquakes are considerably different.