Physically based distributed hydrological models were used to describe small-scale hydrological information in detail. However, the sensitivity of the model to spatially varied parameters and inputs limits the accuracy for application. In this paper, relevant influence factors and sensitive parameters were analyzed to solve this problem. First, a set of digital elevation model (DEM) resolutions and channel thresholds were generated to extract the hydrological influence factors. Second, a numerical relationship between sensitive parameters and influence factors was established to define parameters reasonably. Next, the topographic index (TI) was computed to study the similarity. At last, simulation results were analyzed in two different ways: (1) to observe the change regularity of influence factors and sensitive parameters through the variation of DEM resolutions and channel thresholds and (2) to compare the simulation accuracy of the nested catchment, particularly in the subcatchments and interior grids. Increasing the grid size from 250 m to 1000 m, the TI increased from 9.08 to 11.16 and the Nash-Sutcliffe efficiency (NSE) decreased from 0.77 to 0.75. Utilizing the parameters calculated by the established relationship, the simulation results show the same NSE in the outlet and a better NSE in the simple subcatchment than the calculated interior grids.