Validation of a modified GTNM classification in peri-junctional oesophago-gastric carcinoma and its use as a prognostic indicator

Dickson, Graeme; Singh, Krishna K.; Escofet, Xavier; Kelley, Kate

doi:10.1053/ejso.2001.1200

Cited by 29 publications

(20 citation statements)

References 18 publications

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“…Quantities of studies have indicated that histologic grade should be regarded as a strong predictor of survival and survival always decreases monotonically according to histologic grade (7,8). The relation between histologic grade, metastatic disease and survival may result from the biological behavior of tumor, which still needs further research.…”

Section: Discussionmentioning

confidence: 99%

Patterns of distant organ metastases in esophageal cancer: a population-based study

Zhu

Ren

et al. 2017

J. Thorac. Dis.

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Background: Esophageal cancer is the eighth most common cancer worldwide. The prognosis of esophageal cancer patients is dismal, especially those with distant organ metastasis. However, there are few studies describing the patterns of distant metastasis in esophageal cancer systematically. Results: A total of 9,934 patients were eligible. Liver was the most common metastatic site in the patients of esophageal cancer and followed by lung, bone and brain. Some clinical features, including age, sex, histology type and histologic grade were independent risk factors for different sites of metastasis. Younger age, poorer differentiation, adenoma type and more metastatic sites might lead to poorer prognosis.Conclusions: Our findings revealed the patterns of metastasis in esophageal cancer, which could help clinicians to identify patients with metastasis and provide proper treatment.

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Section: Discussionmentioning

confidence: 99%

Patterns of distant organ metastases in esophageal cancer: a population-based study

Zhu

Ren

et al. 2017

J. Thorac. Dis.

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“…However, several authors have criticised the TNM oesophageal staging system, claiming that it poorly stratifies what is a heterogeneous group of patients who have variable prognostic outcomes and undergo different treatment regimens [12][13][14][15][16][17][18][19][20][21][22][23]. The UICC has responded to these recommendations in its seventh edition of TNM staging, released in 2010, by modifying all three aspects of the scoring system.…”

Section: Introductionmentioning

confidence: 99%

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Kayani

Zacharakis

Ahmed

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Oesophageal cancer is the seventh most common cause of cancer-related death in the developed world and the incidence of oesophageal adenocarcinoma is now the fastest growing of any gastrointestinal cancer. Lymph node involvement is the single most important prognostic factor in oesophageal cancer. Imaging to determine the extent of lymph node involvement and plan treatment often requires a combination of modalities to avoid under-staging. The seventh edition of the staging system released by the International Union Against Cancer (IUCC) has stratified lymph node involvement according to the number of lymph nodes involved and redefined its groupings for location of metastatic lymph node involvement. This review discusses the prognostic and treatment implications of these modifications and explores micrometastatic lymph node involvement, capsular infiltration and lymph node ratio as possible additions to the staging system.

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“…The most widely used staging system is the tumour node metastasis (TNM) system of the American Joint Committee on Cancer 13 and the International Union Against Cancer 14 . Many studies have, however, demonstrated that other clinicopathological factors are significant prognostic variables, such as the location and number of involved nodes 15 -18 , the presence of extracapsular lymph node involvement 19,20 , differentiation grade 21 -23 and resection margin status 21,24 . TNM staging does not take these into account and a variety of revisions has been proposed 21,25 -30 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic nomogram for patients undergoing oesophagectomy for adenocarcinoma of the oesophagus or gastro-oesophageal junction

Lagarde

Reitsma

Castro

et al. 2007

British Journal of Surgery

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Validation of a modified GTNM classification in peri-junctional oesophago-gastric carcinoma and its use as a prognostic indicator

Cited by 29 publications

References 18 publications

Patterns of distant organ metastases in esophageal cancer: a population-based study

Patterns of distant organ metastases in esophageal cancer: a population-based study

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Prognostic nomogram for patients undergoing oesophagectomy for adenocarcinoma of the oesophagus or gastro-oesophageal junction

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