Validation of a new index for estimating arterial stiffness: Measurement of the QPV interval by doppler ultrasound

Lee, Min-Yi; Chu, Chih‐Sheng; Lee, Kun-Tai; Wu, Chan-Ming; Lin, Shin-Jing; Sheu, Sheng-Hsuing; Lai, Wen‐Ter

doi:10.1002/clc.4960290806

Cited by 5 publications

(10 citation statements)

References 19 publications

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“…The lack of an association of the QPV interval with height and heart rate was also noted previously. 9 In the present study, the QPV interval was similar in patients taking and not taking steroids, analogous to prior studies that demonstrated steroid use to have no effect on arterial stiffness. 2 The QPV interval represents the transit time from cardiac ejection to brachial artery flow.…”

Section: Discussionsupporting

confidence: 87%

“…These results are similar to those of Lee et al, who compared the brachial-to-ankle PWV using volume plethysmography to the QPV interval in hypertensive and nonhypertensive normal subjects. 9 Mean QPV values were similar to the QPV values reported in that study. The lack of an association of the QPV interval with height and heart rate was also noted previously.…”

Section: Discussionsupporting

confidence: 87%

“…The QPV interval was measured according to the previously published method as the time intervals expressed in milliseconds between the onset of the QRS complex and the peak brachial artery Doppler flow velocity. 9 The time intervals measured at 3 consecutive velocity waveforms were averaged. The intraobserver and interobserver coefficients of variation between measurements of QPV interval were 6.2% and 5.7%, respectively.…”

Section: Measurement Of the Qpv Intervalmentioning

confidence: 99%

“…8 Recently, the QPV interval, derived from Doppler ultrasound of the brachial artery, has been proposed as a new measure of arterial stiffness. 9 The QPV interval is based on the premise that the transit time from cardiac ejection to brachial artery flow is shortened in patients with increased arterial stiffness. This prior study by Lee et al was designed to determine the validity of the QPV interval in patients with hypertension.…”

Section: Introductionmentioning

confidence: 99%

“…The QPV interval was also shown to inversely correlate with brachial ankle pulse wave velocity (PWV), derived by volume plethysmography. 9 In recent years, assessment of endothelial function by brachial artery ultrasound has grown in the research The study was supported by a grant from the Mary Kirkland Center for Lupus Research, New York, NY, USA.…”

Section: Introductionmentioning

confidence: 99%

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QPV Interval as a Measure of Arterial Stiffness in Women with Systemic Lupus Erythematosus

Qureshi¹,

Salciccioli²,

Lee³

et al. 2009

Clinical Cardiology

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Background: Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis and increased arterial stiffness. The QPV interval has been proposed as a measure of arterial stiffness. The QPV interval is based on the premise that transit time from cardiac ejection to brachial artery flow is shortened in patients with increased arterial stiffness. Hypothesis: The objective of this study was to determine the significance of the QPV interval as a measure of arterial stiffness in patients with SLE. Methods: We prospectively studied 46 female SLE patients. The QPV interval was calculated as the time from onset of the QRS complex to peak flow velocity of the brachial artery during ultrasound examination. Measurements of arterial stiffness: augmentation index (AI) and pulse wave velocity (PWV) were obtained by applanation tonometry while patients were on a stable medical regimen. Results: Mean age was 44±14 y and mean QPV interval was 198±18 msec QPV interval correlated inversely with age (r = −0.39, p = 0.008), AI (r = −0.41, p = 0.004), PWV (r = −0.39, p = 0.007), and aortic pulse pressure (PP) (r = −0.45, p = 0.002). On multivariate regression analysis, QPV interval was found to be an independent predictor of PWV after adjusting for age (R 2 = 0.26, p<0.001). Conclusion:In women with SLE, QPV decreases with age and is inversely related with measures of arterial stiffness. QPV may be useful in identifying SLE patients with higher arterial stiffness in the clinical or research setting. Further larger studies are needed to confirm these preliminary results.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Section: Measurement Of the Qpv Intervalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

QPV Interval as a Measure of Arterial Stiffness in Women with Systemic Lupus Erythematosus

Qureshi¹,

Salciccioli²,

Lee³

et al. 2009

Clinical Cardiology

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Usefulness of Aortic Strain Analysis by Velocity Vector Imaging as a New Echocardiographic Measure of Arterial Stiffness

Kim

Park

Yoon

et al. 2009

Journal of the American Society of Echocardiography

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Comparing the Finapres and Caretaker Systems for Measuring Pulse Transit Time Before and After Exercise

et al. 2011

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We aimed to compare the Finapres system, which is designed for accurate intra-arterial amplitude measurement, to the Caretaker system, which is designed for temporal accuracy of intra-arterial measurement, in regard to measurement of pulse transit time (PTT) at baseline and following an endurance exercise session. Pulse transit time was evaluated between the R-wave of the ECG and the foot of the arterial waveform using either the Finapres (fpPTT) or Caretaker (ctPTT). 23 participants were measured before and after completion of endurance exercise. When comparing PTT values before and after an exercise intervention within devices, ctPTT was significantly different following exercise (P=0.03); however, the Finapres obtained values did not differ significantly. Before exercise, there was no significant relationship between devices, however, after exercise a significant moderate correlation was observed (r=0.45, P=0.02). Significant differences existed between ctPTT and fpPTT (P< 0.001). The Caretaker system appears to be more accurate at detecting changes in PTT occurring as a result of a single aerobic exercise session. This may be due to the servo-controller feedback loop in the waveform contour predicting algorithm within the Finapres system, which is not present in the Caretaker unit. The Finapres system also appears to have an inherent delay in pulse contour reporting.

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Validation of a new index for estimating arterial stiffness: Measurement of the QPV interval by doppler ultrasound

Cited by 5 publications

References 19 publications

QPV Interval as a Measure of Arterial Stiffness in Women with Systemic Lupus Erythematosus

QPV Interval as a Measure of Arterial Stiffness in Women with Systemic Lupus Erythematosus

Usefulness of Aortic Strain Analysis by Velocity Vector Imaging as a New Echocardiographic Measure of Arterial Stiffness

Comparing the Finapres and Caretaker Systems for Measuring Pulse Transit Time Before and After Exercise

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