Validation of a novel diagnostic test for assessing the risk of urinary uric acid crystallization

Calvó, Paula; Costa-Bauzà, Antònia; Gráses, F.; Hernández, Y.; Sanchís, Pilar

doi:10.1016/j.cca.2021.05.001

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…UA crystallization was determined by measuring the formation of UA crystals in polystyrene non-treated culture dishes (Corning, NY, USA), in which 5 mL of urine was maintained for 24 h at room temperature and then carefully removed via aspiration with a pipette. This test is a simplified version of the Risk for UA Crystallization (RUAC) test [ 30 ]. A result was considered positive when UA crystals formed in the dish and negative when the dish contained no crystals ( Figure 9 ).…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis

Costa-Bauzà

Calvó

Hernández

et al. 2023

IJMS

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Uric acid lithiasis accounts for about 10% of all types of renal lithiasis. The most common causes of uric acid lithiasis are low urinary pH, followed by high concentration of urinary uric acid, and low diuresis. Treatment of patients consists of alkalinization of urine, reducing the consumption of purine-rich foods, and administration of xanthine oxidase inhibitors, because there are no established therapeutic inhibitors of uric acid crystallization. We recently found that theobromine inhibited uric acid crystallization in vitro, and that the increased urinary level of theobromine following its oral consumption was associated with the prevention of uric acid crystallization. In this study, we evaluated the inhibitory effects of theobromine metabolites and other methylxanthine-related compounds on uric acid crystallization. We also measured the urinary concentrations of theobromine and its metabolites in samples from healthy individuals and patients with uric acid stones and compared the extent of uric acid supersaturation and uric acid crystal formation in these different samples. Theobromine and other methylxanthines that lacked a substituent at position 1 inhibited uric acid crystallization, but other methylxanthines did not have this effect. Individuals with clinical parameters that favored uric acid crystallization did not develop uric acid crystals when theobromine and its metabolites were in the urine at high levels. Thus, theobromine and its metabolites reduced the risk of uric acid lithiasis.

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Section: Methodsmentioning

confidence: 99%

Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis

Costa-Bauzà

Calvó

Hernández

et al. 2023

IJMS

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“…Their frequent consumption promotes oxalate stones formation. Cocoa contains theobromine which reduce a risk of uric acid stone formation (34). Nuts (average content of fats in food -øF = 52 g/100 g), cheese (øF = 28 g/100 g) and poultry (øF = 25 g/100 g) are rich in fats and may increase weight and BMI.…”

Section: S41mentioning

confidence: 99%

Analysis of potential risk factors associated with urolithiasis

Drabiščák¹,

Dorko²,

Vargovčák³

et al. 2022

Cent Eur J Public Health

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Objectives: Eating habits, regular fluid intake, lifestyle and body composition are a primary point of research. The research focused on urolithiasis approaching potential danger, trying to interpret risk factors responsible for urolithiasis and disease recurrence.Methods: Research file contains 166 patients suffering from urolithiasis, 87 (52.4%) males and 79 (47.6%) females, and 172 healthy subjects from control group. All data was accessed using fully anonymous and confidential questionnaires, then evaluated in the statistical GNU PSPP 1.4 software.Results: More than ¾ patients have a BMI higher than 24.9 and almost 40% of subjects have obesity class I, II, or III. Patients have higher BMI than subjects (d = 1.285; p < 0.001), and females have significantly higher BMI than males (d = 0.385; p = 0.007). Female patients have higher BMI than Slovak healthy females (p < 0.001; MD = 4.581; CI: 3.24-5.93). Patients have a lower daily water intake than subjects (φc = 0.157; p = 0.04) and more than 2 /3 of patients have insufficient water intake. Sedentary employment prevails markedly in patients than in subjects. Patients are much less physically active than subjects (φc = 0.633; p < 0.001) and the difference is rising with increasing age of patients (ρ = − 0.232; p = 0.003). Low physical and working activity are characteristic for patients in this study. Patients smoke more often in comparison to subjects (φc = 0.261; p < 0.001). Patients consume more meats (red and white), cocoa and lentils. A lot of patients exceed recommended daily intake of pork and beef.Conclusions: Many conditions are different for the healthy population and patients' group. High BMI, low fluid intake, exceeded red meat consumption, and low physical activity are the strongest factors for developing urolithiasis. Patients should consume more fluids daily, exercise frequently and vigorously, and lower amount of red meat consumed.

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Validation of a novel diagnostic test for assessing the risk of urinary uric acid crystallization

Cited by 2 publications

References 21 publications

Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis

Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis

Analysis of potential risk factors associated with urolithiasis

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