Validation of a Questionnaire for Clinical Seizure Diagnosis

Reutens, David C.; Howell, R A; Gebert, K E; Berkovic, Samuel F.

doi:10.1111/j.1528-1157.1992.tb01760.x

Cited by 120 publications

(85 citation statements)

References 9 publications

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“…A much better degree of agreement between observers for ICES has also been reported in studies using semistructured interviews (16,19,20), but this again involves additional information, not directly related to the seizure phenomena itself.…”

Section: Discussionmentioning

confidence: 67%

Classification of Epileptic Seizures: A Comparison of Two Systems

Parra

Augustijn

Geerts³

et al. 2001

Epilepsia

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Summary:Purpose: Extensive experience with video-EEG seizure monitoring, notably in the setting of epilepsy surgery programs, has exposed the limited value of the current International Classification of Epileptic Seizures (ICES) for providing relevant localizing information. To overcome this limitation, a Semiologic Seizure Classification (SSC) has recently been proposed. This study aimed to assess and to compare the usefulness and reliability of both systems in the setting of a tertiary epilepsy center.Methods: Three epileptologists independently reviewed video-taped seizures, randomly selected from the archive of the Epilepsy Monitoring Unit. They were blinded to the EEG findings and final diagnosis and classified all seizures according to both classifications.Results: One hundred thirty-eight seizures from 60 patients (age range, 2-59 years) were reviewed (maximum, three seizures per patient). Fifty-five seizures from 20 patients were recorded in the setting of presurgical evaluations, and the remainder as part of regular diagnostic evaluations. The average interobserver agreement was higher for SSC (63.3%, ‫ס‬ 0. 56) than for ICES (38.6%, ‫ס‬ 0.41). Some categories of SSC, such as hypermotor or automotor, had the best interobserver agreement, and were strongly correlated with the anatomic localization of the seizures (frontal and temporal lobe, respectively). All reviewers agreed that SSC provided a better description of the seizures than did ICES, in 60% of the patients.Conclusions: SSC provides a more comprehensive picture of epileptic seizures than does ICES, notably in patients with localized epilepsy syndromes, and appears to be very useful and reliable, particularly in the setting of specialized epilepsy centers.

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Section: Discussionmentioning

confidence: 67%

Classification of Epileptic Seizures: A Comparison of Two Systems

Parra

Augustijn

Geerts³

et al. 2001

Epilepsia

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“…This being so, the mechanisms involved in any change within the child or mother are likely to be less straightforward and conventional hypothesis testing may be 3 Epilepsy too simplistic. Seizure type was assessed by means of a structured interview (Reutens et al 1992) comprising of 26 main questions, including…”

Section: Body Movements Visit Fourmentioning

confidence: 99%

Behavioural treatment for sleep problems in children with severe learning disabilities and challenging daytime behaviour: Effect on sleep patterns of mother and child

Wiggs

Stores

1998

Journal of Sleep Research

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SUMMARYChildren with sleep problems present serious management problems to their parents.Such children are also more likely to have additional problems, behavioural disturbance being particularly common. This randomized controlled trial of behavioural interventions for the children's sleep problems was conducted to explore the efficacy and mechanisms of treatment in children with the most extreme forms of problems: severe learning disabilities, severe sleep problems and severe daytime challenging behaviour. Fifteen index families received behavioural advice for the child's sleep problem and were compared with 15 matched controls who received no such advice. Repeat assessments of the children's and mothers' sleep were made by parental report as well as actometry. Objective changes in the children's sleep quality and quantity were not seen after treatment. However, mothers in the treatment group reported improvements in the children's sleep problems and had an increased sleeping time themselves following treatment.The results indicate that sleep problems can be successfully treated in this group of children, although the mechanisms of treatment may not be as direct as supposed. This has implications for understanding of sleep problems in children with learning disabilities and also for clinical practice, when considering ways of offering help to these highly 'challenged' families. actometry, behavioural treatment, challenging behaviour, sleep INTRODUCTIONBehavioural interventions have been used successfully to treat the sleep problems of children with learning disabilities Consistently high rates of sleep problems are reported in (e.g. Quine 1992). However, there have been no investigations children with learning disabilities (Bartlett et al. 1985; Quine of children's sleep which have focused solely on children with 1991; Wiggs and Stores 1996). Work has indicated that children challenging behaviour. Previous behavioural intervention with severe learning disabilities and sleep problems are more studies, both in the general population and in children with likely to have more severe and more coexistent challenging learning disabilities, have selected subjects with sleep problems, behaviour than children without sleep problems (Wiggs and of which only a minority have had behaviour disorders at the Stores 1996). Challenging behaviour refers to behaviour which onset (e.g. Seymour et al. 1983;Sanders et al. 1984; Richman includes injury to the child or others, damage or destruction et al. 1985; Quine 1992; Minde et al. 1994). Therefore, it is not to the environment or social disruption affecting the lives of known whether it is possible to successfully treat sleep problems the child or others (Emerson et al. 1987;Mansell 1994).by behavioural methods in children who also have challenging behaviour and what the effects of successful treatment might be upon the child and parent.

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“…Clinical data and a detailed family history were obtained using a validated seizure questionnaire and personal evaluation and review of medical records, including EEG and neuroimaging investigations. 9 MRI (generally 1.5T) was performed in 243 of 251 patients and showed no acquired lesion (tumor, trauma, stroke, etc.). Hippocampal sclerosis was allowed because although it may follow prolonged febrile convulsion or cerebral infection, a heritable component has been reported, including mutations in the SCN1A 10 and SCN1B…”

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confidence: 99%

A targeted resequencing gene panel for focal epilepsy

et al. 2016

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Objectives: We report development of a targeted resequencing gene panel for focal epilepsy, the most prevalent phenotypic group of the epilepsies. Methods:The targeted resequencing gene panel was designed using molecular inversion probe (MIP) capture technology and sequenced using massively parallel Illumina sequencing.Results: We demonstrated proof of principle that mutations can be detected in 4 previously genotyped focal epilepsy cases. We searched for both germline and somatic mutations in 251 patients with unsolved sporadic or familial focal epilepsy and identified 11 novel or very rare missense variants in 5 different genes: CHRNA4, GRIN2B, KCNT1, PCDH19, and SCN1A. Of these, 2 were predicted to be pathogenic or likely pathogenic, explaining ;0.8% of the cohort, and 8 were of uncertain significance based on available data. Conclusions:We have developed and validated a targeted resequencing panel for focal epilepsies, the most important clinical class of epilepsies, accounting for about 60% of all cases. Our application of MIP technology is an innovative approach that will be advantageous in the clinical setting because it is highly sensitive, efficient, and cost-effective for screening large patient cohorts. Our findings indicate that mutations in known genes likely explain only a small proportion of focal epilepsy cases. This is not surprising given the established clinical and genetic heterogeneity of these disorders and underscores the importance of further gene discovery studies in this complex syndrome. Neurology ® 2016;86:1605-1612 GLOSSARY ExAC 5 Exome Aggregation Consortium; MIP 5 molecular inversion probe; NFLE 5 nocturnal frontal lobe epilepsy; smMIP 5 single molecule molecular inversion probe; TLE 5 temporal lobe epilepsy.

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Validation of a Questionnaire for Clinical Seizure Diagnosis

Cited by 120 publications

References 9 publications

Classification of Epileptic Seizures: A Comparison of Two Systems

Classification of Epileptic Seizures: A Comparison of Two Systems

Behavioural treatment for sleep problems in children with severe learning disabilities and challenging daytime behaviour: Effect on sleep patterns of mother and child

A targeted resequencing gene panel for focal epilepsy

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