Validation of a technique using microbubbles and contrast enhanced ultrasound (CEUS) to biopsy sentinel lymph nodes (SLN) in pre-operative breast cancer patients with a normal grey-scale axillary ultrasound

Contrast Enhanced Ultrasound (CEU) Using Microbubbles for Sentinel Lymph Node Biopsy in Breast Cancer: a Systematic Review

“…A total of 14, 23 and 67 studies in PubMed, Scopus and Cochrane libraries search were retrieved, respectively, among which 5 studies that met the inclusion criteria of our systematic review (15)(16)(17)(18)(19). No additional studies were found through hand-searching of references.…”

Percutaneous Sentinel Node Biopsy in Breast Cancer: Results of a Phase 1 Study

“…Cox et al noted that 55 % of false negatives on core biopsy were micrometastasis on ALND, suggesting that core may be more clinically relevant. 14 In the current study, if we consider whether the core biopsy result accurately represents the nodal stage, the core was benign in pathological N0 stage in 88 % of cases (22 of 25).…”

“…They noted a biopsy tract within the SLN in 87 % of cases when FNA was used and 93 % of cases with core biopsy and demonstrated 60 % sensitivity and 100 % specificity for LN metastasis using this technique. 14 Two prior studies have reported use of a gamma probe in combination with ultrasound guidance for SLN identification in breast cancer patients undergoing dual tracer SLND. Whelehan et al assessed the accuracy of percutaneous identification of the SLN using a gamma probe combined with ultrasound guidance in clinically nodenegative breast cancer patients.…”

160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

“…per groin, range [4][5][6][7][8][9][10][11][12][13][14], of which 109 were SLNs (mean 2.2 nodes (SD 1.4) per groin, range 1-7).…”

“…[9] This has led to interest in the development of novel techniques not reliant upon radioisotopes (our Lancet reference in press -will be published by the time this is accepted) which are currently restricted uptake of dye by higher echelon nodes [10][11][12] and high false negative rates. [13] (This seems a nonsequitur -what does it mean?) The magnetic technique, developed by Douek et al (ref), is one of the most promising alternatives.…”