Validation of a Time Dependent Physio-Chemical Model for Thrombus Formation and Growth

Abstract

In this study, a shear-dependent continuum model for platelet activation, adhesion and aggregation is validated using computational fluid dynamics (CFD). To take the presence of red cells into account, a combination of excess-platelet boundary layer and enhanced mass diffusivity of platelets and large species is used to mimic this behavior. The model has been validated under three different shear conditions and two different heparin levels. Also three-dimensional simulations were carried out to evaluate the model’s prediction of thrombus growth rate for stenosed tubes under various flow conditions and stenosis degrees. For these cases, also the effect of change in platelet diffusivity has been investigated by using an empirical correlation for enhanced diffusivity of platelets. For all 3D simulations, results for thrombus growth rate as a function of local wall shear rate were compared to those of experiments and numerical studies in the literature and an acceptable agreement was achieved.

Modeling thrombus formation and growth

“…For platelets in PRP, it can be assumed that they diffuse in plasma solely due to their Brownian motion (D b;PLT ). However, in whole blood the diffusion coefficient of platelets can be dramatically augmented (up to three orders of magnitude) due to margination (Hosseinzadegan and Tafti, 2016). This effect, referred to as the shear-enhanced or the shear rate-dependent mass diffusivity of Figure 4.…”

A review of fatigue and fracture mechanics with a focus on rubber-based materials

“…Hence, this method could be coupled with atomistic-continuum simulations. [33][34][35][36] It was also concluded that the method for estimation of the resistance to defect propagation in nanoscales could be used in traction-separation law in continuum mechanics. V-notches and U-notches are complex defects, which should be accurately evaluated by applying the J-integral method.…”