Validation of Addenbrooke’s Cognitive Examination (ACE) in a Persian-Speaking Population

Background:Dementia as a major cognitive neurological disorder is defined as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient's independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the efficacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia.Methods:This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015–2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and R. damascena capsules, and in control group, placebo capsule instead of R. damascena added on donepezil. Four test was filled three times at the study initiation, after month one and also after month three: Mini–Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were filled.Results:The results showed add-on donepezil and R. damascena versus placebo improved cognitive impairment based on MMSE with P = 0.002, ACE-R with total P = 0.001, depression (P = 0.012), behavioral disorders (P < 0.001), and daily activity (P < 0.001).Conclusions:The R. damascena extract affected cognitive impairment of dementia patients significantly and also have significant effects on improving depression and behavioral problems.

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“…Sensitivity and specificity of Persian format of this test was 91% and 93%, respectively, with the cutoff of 78. [ 19 ]…”

Section: Methodsmentioning

confidence: 99%

Novel effects of Rosa damascena extract on patients with neurocognitive disorder and depression: A clinical trial study

et al. 2018

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“…A score between 78 and 85 showed mild cognitive impairment, and less than 78 was indicative of AD. The calculated Cronbach's alpha in this study was 0.84 overall (24).…”

Section: Methodsmentioning

confidence: 49%

Post-Treatment Neurocognitive Disorders in Adults with Frontal or Parietal Astrocytomas

Anvari

Salek

Fanipakdel

et al. 2016

Rep Radiother Oncol

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Background: High-grade astrocytomas are among the most common neuroepithelial brain tumors. Because of their highly malignant nature, in most cases, in addition to maximal resection, they also require adjuvant treatments, such as chemotherapy and radiotherapy. A common accompanying condition, which may occur with this type of clinical presentation, is cognitive disorders. These can be caused by the tumor itself, the treatment used or may be patient related. The aim of this study was to evaluate the level of cognitive ability in patients with astrocytoma compared to the normal population and evaluating the factors possibly affecting them. Methods: A case-control study was performed on 30 adults referred to Imam Reza and Omid hospitals, Mashhad, Iran, during year 2014. The studied patients had astrocytomas, for which they had performed surgery. All patients had also received radiotherapy. The control group consisted of 30 healthy individuals, among the patients' family members, who were matched for age and gender with the patients. The tools used in this study were a checklist for demographic data, and the Farsi version of Addenbrook's cognitive questionnaire. Data were entered in the SPSS 22 software and analyzed using the Student's t test and Mann-Whitney test. P values of

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“…Additionally, the cognitive profile differed significantly amongst the psychiatric and dementia subgroups, suggesting that the NUCOG may offer clinicians additional utility in the diagnostic process. Besides the MMSE, the only other cognitive assessment tool available in Persian is the ACE, which has recently also been validated in a Persian-speaking population although this study used a smaller sample size (n = 135) and only included controls, individuals diagnosed with MCI and patients with SDAT, with the aim of distinguishing these three groups from each other [15] . This study showed that the ACE strongly differentiated MCI and SDAT from the healthy control group, and that the ACE significantly outperformed the MMSE with regard to sensitivity and specificity in discriminating SDAT and MCI from healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Validity and Reliability of the Persian Language Version of the Neuropsychiatry Unit Cognitive Assessment Tool

Barekatain

Walterfang

Behdad

et al. 2010

Dement Geriatr Cogn Disord

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Background/Aims: Only a limited number of cognitive screening tools are available for the Persian-speaking population, and we sought to translate and validate the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), a multidimensional cognitive screening tool. Methods: We used multiple language specialists to translate and then back-translate the NUCOG, and administered the Persian language NUCOG and Mini-Mental State Examination (MMSE) to 184 individuals: 60 controls and 124 patients, 33 of whom had dementia, 30 non-dementing neurological disorders and 61 a psychiatric illness. Results: The NUCOG outperformed the MMSE in differentiating the patient groups and controls. The ‘profile’ across the 5 NUCOG domains differentiated dementia subgroups such as senile dementia of the Alzheimer type (SDAT), frontotemporal dementia and mild cognitive impairment (MCI). Psychiatric patients with psychosis and posttraumatic stress disorder were more impaired than patients with affective disorders. The NUCOG reliably differentiated controls from patients with MCI (at 86.5/100, sensitivity of 83.3% and specificity of 87.5%) and SDAT (at 75/100, sensitivity and specificity of 100%) patients from controls. Conclusions: The Persian language NUCOG appears to perform strongly in an unselected population, reliably differentiating patients with dementia from controls, and detecting cognitive impairment in a range of clinical disorders.

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Validation of Addenbrooke’s Cognitive Examination (ACE) in a Persian-Speaking Population

Cited by 39 publications

References 23 publications

Novel effects of Rosa damascena extract on patients with neurocognitive disorder and depression: A clinical trial study

Novel effects of Rosa damascena extract on patients with neurocognitive disorder and depression: A clinical trial study

Post-Treatment Neurocognitive Disorders in Adults with Frontal or Parietal Astrocytomas

Validity and Reliability of the Persian Language Version of the Neuropsychiatry Unit Cognitive Assessment Tool

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