In this study, a multi-objective optimization method was used to improve the mechanical properties and manufacturing conditions of reinforced polyamide 66+PA6I/6T polymer based on injection molding process parameters. For that purpose, the combined approach of response surface methodology (RSM) and Grey Wolf Optimization (GWO) was proposed to minimize and model the quality parameters such as warpage, volumetric shrinkage, and cycle time of the polymer. In the study, Moldflow Insight software was used to simulate and obtain the numerical objective results based on design parameters including fiber ratio, mold temperature, melt temperature, injection pressure, and injection time. Based on optimized design parameters, a test specimen was produced in an injection molding machine to obtain and compare the tensile test results. The Box-Behnken method was applied for the experimental design of the numerical analysis, and the analysis of variance (ANOVA) method was used to investigate the effect of design parameters on the objective parameters in molding. According to the numerical results, it was found that both RSM and GWO methods gave better results than the quality results obtained by the recommended process parameter results as well as these results were consistent with the ANOVA results. It was determined that the RSM was more effective than the GWO method for this experimental design. Also, it was concluded that according to the experimental tensile test results, the best tensile test result was obtained by 60% fiber reinforcement, and the tensile module value increased by 39,4% for this addition ratio based on the optimized process parameters.