Validation of biological markers for quantitative risk assessment.

Schulte, Paul A.; Mazzuckelli, Lawrence F.

doi:10.1289/ehp.90-1519476

Cited by 14 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When compared to traditional exposure modeling, biological monitoring can reduce the uncertainty in exposure estimates as it detects the concentrations of substances in biologic tissue, such as blood, urine, and hair. 40,101,102,135 Biological monitoring techniques have been validated as an effective index for assessing environmental exposure levels. 113,120 However, biological monitoring cannot interpret the adverse health effects of air pollution, since there is a lack of understanding of interactions between health effects and multiple pollutants and toxins, particularly at very low chemical concentrations.…”

Section: Discussion and Recommendationsmentioning

confidence: 99%

“…Biomarkers have a potential value as proxy measures of disease outcome, calibration of other exposure model estimates, and as a means of distinguishing individuals who may be unusually susceptible to the effects of a pollutant. 40,[101][102][103] Until now, a large number of studies utilizing biomarkers to assess air pollution exposure have been conducted. Early work in the 1980s included Ehrenberg and Osterman-Golkar's 104 study utilizing biomarkers to quantitatively estimate exposure and to predict relative risks for cancer.…”

Section: Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Air pollution exposure assessment methods utilized in epidemiological studies

et al. 2009

View full text Add to dashboard Cite

The assessment of personal exposure to air pollution is a critical component of epidemiological studies associating air pollution and health effects. This paper critically reviewed 157 studies over 29 years that utilized one of five categories of exposure methods (proximity, air dispersion, hybrid, human inhalation, and biomarkers). Proximity models were found to be a questionable technique as they assume that closer proximity equates to greater exposure. Inhalation models and biomarker estimates were the most effective in assessing personal exposure, but are often cost prohibitive for large study populations. This review suggests that: (i) factors such as uncertainty, validity, data availability, and transferability related to exposure assessment methods should be considered when selecting a model; and (ii) although an entirely discreet new class of approach is not necessary, significant progress could be made through the development of a 'hybrid' model utilizing the strengths of several existing methods. Future work should systematically evaluate the performance of hybrid models compared to other individual exposure assessment methods utilizing geospatial information technologies (e.g. geographic information systems (GIS) and remote sensing (RS)) to more robustly refine estimates of ambient exposure and quantify the linkages and differences between outdoor, indoor and personal exposure estimates.

show abstract

Section: Discussion and Recommendationsmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

Air pollution exposure assessment methods utilized in epidemiological studies

et al. 2009

View full text Add to dashboard Cite

show abstract

“…C57BL/6 male mice were obtained from Simonsen Laboratory (Gilroy, CA) at 6-8 weeks of age and allowed to acclimatize for 1 week. For determination of the distribution and fate of PhIP, the mice were administered [2-14CT-labeled PhIP (50 mCi/mmole) by stomach intubation at a dose of 41 ng/kg body weight.…”

Section: Methodsmentioning

confidence: 99%

Low-Level Biological Dosimetry of Heterocyclic Amine Carcinogens Isolated from Cooked Food

Turteltaub¹,

Vogel²,

Frantz³

et al. 1993

Environmental Health Perspectives

View full text Add to dashboard Cite

The bioavailability and the bioreactivity of the carcinogenic heterocyclic amine [2-'4CJ2-amino-1-methyl-6phenylinidazo[4,5-blpyridine (PhIP) have been investigted d a dose a in that likluy from thehuman diet by accelerator mass spectrometry (AMS). [2-_4CJPhIP mus administered to mice at a dose equivalent to the consumption of two 100 g beef patties (41 ng/kg). The biological halflife of PhIP was 1 hr, with 90% ofthe dose being excreted via the urine. Peak tissue PhEP concentrations were reached within 3 hr, with the highest levels in the tissues ofthe gastrointestil tract, followed by the liver, kidney, pancreas, and thymus. Since the detection limit by AMS is dependent on the natural abundance of 14C, we have achieved further increases in sensitivity by producing mice that have 20% ofthe naturl abundance of 14C. Use of these 14C-depleted aniS all Ms rementS to be made near the natural lvel ofexore for many environmental carcinogens. PhIP-DNA adduct levels havealso been measured by 32P-postlabeling at doses of 1.0 , and 20 mg/kg. The highest adduct levels were found in the pancreas, thynms, heart, and iver and increased linearly with dose. The principal adducts are derived from guanine.

show abstract

“…A biomarker can be any substance, structure or process that can be monitored in tissues or fluids and that predicts or influences health; or that assesses the incidence or biological behavior of a disease, but is not a measure of disease, disorder or health condition itself [15],[16]. Ideally, biomarkers should be accessible (non-invasive), non-destructive, easy and cheap to measure [17],[18].…”

Section: Biomarkers Of Genotoxicitymentioning

confidence: 99%

The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies

Ladeira

Smajdova

2017

AIMS Genetics

View full text Add to dashboard Cite

Molecular epidemiology is an approach increasingly used in the establishment of associations between exposure to hazardous substances and development of disease, including the possible modulation by genetic susceptibility factors. Environmental chemicals and contaminants from anthropogenic pollution of air, water and soil, but also originating specifically in occupational contexts, are potential sources of risk of development of disease. Also, diet presents an important role in this process, with some well characterized associations existing between nutrition and some types of cancer. Genotoxicity biomarkers allow the detection of early effects that result from the interaction between the individual and the environment; they are therefore important tools in cancer epidemiology and are extensively used in human biomonitoring studies. This work intends to give an overview of the potential for genotoxic effects assessment, specifically with the cytokinesis blocked micronucleus assay and comet assay in environmental and occupational scenarios, including diet. The plasticity of these techniques allows their inclusion in human biomonitoring studies, adding important information with the ultimate aim of disease prevention, in particular cancer, and so it is important that they be included as genotoxicity assays in molecular epidemiology.

show abstract

Validation of biological markers for quantitative risk assessment.

Cited by 14 publications

References 21 publications

Air pollution exposure assessment methods utilized in epidemiological studies

Air pollution exposure assessment methods utilized in epidemiological studies

Low-Level Biological Dosimetry of Heterocyclic Amine Carcinogens Isolated from Cooked Food

The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies

Contact Info

Product

Resources

About