Validation of Capsule Endoscopy Crohn's Disease Activity Score (CECDAI or Niv Score) – A Multi Center Prospective Study

Niv, Yaron; Ilani, Sagi; Levi, Zohar; Hershkowitz, M; O’Moráin, Colm; O’Donnell, Sarah; Scapa, Eitan; Eliakim, Rami; Kalantzis, Nickolas; Fireman, Zvi; Gal, Eyal

doi:10.1016/s0016-5085(11)63186-7

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…VCE is highly sensitive in the detection of superficial lesions of the mucosa and several studies have demonstrated it to be superior to MRE and enteroscanner for diagnosis in patients suspected of CD (Se 100%, Spe 91% versus 81% and 86% versus 76% and 85%, respectively) [37]. Disease activity is currently characterized using two scoring systems: the Lewis score, recently validated 53 and the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) [53,54]. The Lewis score analyses 3 mucosal parameters (villous appearance, ulcerations and stenosis) in each of the 4 segments of the small intestine (duodenum, jejunum, proximal and distal ileum).…”

Section: Videocapsule Endoscopymentioning

confidence: 99%

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Auzoux¹,

Boschetti²,

Lahlou³

et al. 2017

J Clin Gastroenterol Hepatol

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In recent decades, the advent of biological therapy has changed the treatment of inflammatory bowel disease (IBD) and has opened new therapeutic endpoints such as mucosal healing (MH). MH incorporated with clinical remission presents a new concept: deep remission, which correlates with a decrease in hospitalization and surgery and improvement in the patient's quality of life. Several techniques can be used to assess mucosal healing such as endoscopy which remains the gold standard. But considerable variations may exist in the interpretation of the definition of mucosal healing which may also be histological or evaluated by radiological or biological methods. Thus, it is important to study mucosal inflammation by endoscopic scores and by new, more sensitive techniques such as videocapsule endoscopy (VCE), magnetic resonance enterography (MRE), chromoendoscopy and confocal laser endomicroscopy (CLE). Biomarkers, such as fecal calprotectin (FC) were also studied in the evaluation of MH and showed positive results. These methods are currently the subject of validation studies.

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Section: Videocapsule Endoscopymentioning

confidence: 99%

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Auzoux¹,

Boschetti²,

Lahlou³

et al. 2017

J Clin Gastroenterol Hepatol

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“…The Lewis Score (LS) and the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) have been validated as cumulative quantitative scores that measure the severity of inflammatory activity, and contribute to standardise reporting and increase interobserver agreement. 47,48 A software application for the automatic calculation of the LS is available in the Rapid Reader ® workstation (Given Imaging, Yokneam, Israel). However, although these scoring systems can quantitatively describe the type, distribution and severity of mucosal lesions, they cannot be used independently as a diagnostic tool, as they grade inflammatory activity regardless of its etiology.…”

Section: Crohn's Diseasementioning

confidence: 99%

“…The use of validated quantitative scales with good inter-observer agreement such as the Lewis score 59 or the CECDAI, 47 with adoption of a standardized definition of mucosal healing, seems particularly relevant in this setting. SBCE enables a longitudinal assessment of the course of the disease and its response to medical therapy.…”

Section: Assessment Of Mucosal Healingmentioning

confidence: 99%

Current Clinical Indications for Small Bowel Capsule Endoscopy

Rosa

Cotter

2015

Acta Med Port

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RESUMOIntrodução: A enteroscopia por cápsula é o exame de primeira linha no diagnóstico de diversas patologias do intestino delgado. Este artigo tem por objectivo rever e analisar criticamente as indicações actuais para enteroscopia por cápsula na prática clínica. Material e Métodos: Revisão bibliográfica suportada em artigos indexados na PubMed. Resultados e Discussão: A enteroscopia por cápsula permite a avaliação não invasiva da mucosa do intestino delgado, com elevado rendimento diagnóstico. Em doentes com hemorragia digestiva de causa obscura, o rendimento da enteroscopia por cápsula aumenta quando realizada precocemente após o evento hemorrágico. O tratamento das angiectasias com enteroscopia assistida por balão permite diminuir a recidiva hemorrágica, enquanto o risco de recidiva em doentes com enteroscopia por cápsula "negativa" é controverso. A entero-TC/entero-RM podem superiorizar-se à enteroscopia por cápsula no diagnóstico de alguns tumores. O 'Smooth Protruding Index on Capsule Endoscopy' (score SPICE) auxilia na diferenciação entre verdadeiros tumores submucosos e abaulamentos não patológicos. A enteroscopia por cápsula é valiosa em doentes com suspeita de doença de Crohn quando a ileocolonoscopia não é diagnóstica, permitindo também estadiar a extensão e actividade das lesões em doentes com diagnóstico prévio de doença de Crohn, com potenciais implicações prognósticas e terapêuticas. A enteroscopia por cápsula permite ainda o diagnóstico de complicações em doentes com doença celíaca refractária. Conclusões: Actualmente, a importância da enteroscopia por cápsula é reconhecida no contexto da hemorragia digestiva de causa obscura e/ou suspeita de tumores do intestino delgado, bem como na suspeita de doença de Crohn ou em doentes com doença de Crohn conhecida para determinar a localização, extensão e actividade da doença, e ainda para a investigação de doentes com doença celíaca refractária. Palavras-chave: Doenças Intestinais; Endoscopia por Cápsula. ABSTRACT Introduction:Small bowel capsule endoscopy is currently the first line diagnostic examination for many diseases affecting the small bowel. This article aims to review and critically address the current indications of small bowel capsule endoscopy in clinical practice. Material and Methods: Bibliographic review of relevant and recent papers indexed in PubMed.

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Capsule endoscopy in the diagnosis of Crohn’s disease

Niv¹

2013

MDER

Self Cite

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Crohn’s disease is a chronic inflammatory disorder affecting any part of the gastrointestinal tract, but frequently involves the small and large bowel. Typical presenting symptoms include abdominal pain and diarrhea. Patients with this disorder may also have extraintestinal manifestations, including arthritis, uveitis, and skin lesions. The PillCam™SB capsule is an ingestible disposable video camera that transmits high quality images of the small intestinal mucosa. This enables the small intestine to be readily accessible to physicians investigating for the presence of small bowel disorders, such as Crohn’s disease. Four meta-analyses have demonstrated that capsule endoscopy identifies Crohn’s disease when other methods are not helpful. It should be noted that it is the best noninvasive procedure for assessing mucosal status, but is not superior to ileocolonoscopy, which remains the gold standard for assessment of ileocolonic disease. Mucosal healing along the small bowel can only be demonstrated by an endoscopic procedure such as capsule endoscopy. Achievement of long-term mucosal healing has been associated with a trend towards a decreased need for hospitalization and a decreased requirement for corticosteroid treatment in patients with Crohn’s disease. Recently, we have developed and validated the Capsule Endoscopy Crohn’s Disease Activity Index (also known as the Niv score) for Crohn’s disease of the small bowel. The next step is to expand our score to the colon, and to determine the role and benefit of a capsule endoscopy activity score in patients suffering from Crohn’s ileocolitis and/or colitis. This scoring system will also serve to improve our understanding of the impact of capsule endoscopy, and therefore treatment, on the immediate outcome of this disorder. As the best procedure available for assessing mucosal status, capsule endoscopy will provide important information about the course and outcome of Crohn’s disease.

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Validation of Capsule Endoscopy Crohn's Disease Activity Score (CECDAI or Niv Score) – A Multi Center Prospective Study

Cited by 4 publications

References 19 publications

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Current Clinical Indications for Small Bowel Capsule Endoscopy

Capsule endoscopy in the diagnosis of Crohn’s disease

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Validation of Capsule Endoscopy Crohn's Disease Activity Score (CECDAI or Niv Score) – A Multi Center Prospective Study

Cited by 4 publications

References 19 publications

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Current Clinical Indications for Small Bowel Capsule Endoscopy

Capsule endoscopy in the diagnosis of Crohn&rsquo;s disease

Contact Info

Product

Resources

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Capsule endoscopy in the diagnosis of Crohn’s disease