Validation of cardio-ankle vascular index as a marker of risk of stroke in older adults in St Petersburg and Bashkortostan

Turusheva, Anna V.; Kotovskaya, Yu. V.; Фролова, Е В; Киселева, Г В

doi:10.18705/1607-419x-2019-25-3-258-266

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…The upper arm and ankle pulse waves, as well as blood pressure are measured. CAVI is disregarded if the ankle-brachial index is less than 0.9 6,8 In a previous study, we obtained equations for calculating the predicted CAVI for older people in Bashkortostan and then confirmed this result during an external validation in the population from St. Petersburg 9 . These equations were used in current study as follows: CAVI above the predicted value in accordance with the proposed formula was considered as a high CAVI.…”

Section: Main Study Parametersmentioning

confidence: 59%

“…20 The Rockwood cumulative deficit Frailty Index, that was used in The Framingham Heart Study, includes questions about the presence of CVD (hypertension, stroke, myocardial infarction, angina, and heart failure), arthritis comorbidity and diabetes, that associate with arterial stiffness on their own. 9,15,[21][22][23][24] Consequently, it explain an association between the Rockwood cumulative deficit Frailty Index and arterial stiffness. 25 We used a 7-item frailty screening scale, that is a cumulative deficit model of frailty, but unlike the Rockwood cumulative deficit Frailty Index, it does not include CVD and other diseases that are associated with vascular stiffness and does not directly evaluate muscle mass and strength as a phenotype frailty model.…”

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confidence: 98%

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<p>Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults</p>

Turusheva¹,

Фролова²,

Kotovskaya³

et al. 2020

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This study was conducted to investigate the relationships between arterial stiffness, frailty and fall-related injuries among community-dwelling older adults. Materials and Methods: A cross-sectional study of a random sample of older adults aged 60 years and older was conducted. Main study parameters: arterial stiffness was measured by the determining the cardio-ankle vascular index (CAVI); Frailty status was defined using a 7item frailty screening scale, developed in Russia. This questionnaire included question about falls and fall-related injuries. Orthostatic test and anthropometric tests were done. Medical history (comorbidity, medications), the Osteoporosis Self-assessment Tool (OST), nutritional, physical, cognitive and functional status were evaluated. Results: The study population included 163 people aged 60-89 years. The average predicted value of CAVI in women aged 60-69 was 9.13 ± 0.13, in men, 9.49 ± 0.05; in women aged 70-79, it was 9.49 ± 0.16, in men, 9.73 ±0.11; in women aged 80 and older it was 10.04 ±0.18, in men, 10.24 ±0.10 units. The CAVI above the predicted value was associated with fall-related injuries even after adjustment for age, sex, use of β-blockers (BBs), history of stroke, and region of residence with the odds ratio 3.52 (95% CI: 1.03 −12.04). Conclusion: Our study revealed an independent association between arterial stiffness and fall-related injuries in older adults over 60 years. The findings suggest that clinicians, especially geriatricians, should pay attention to arterial stiffness of patients with fall-related injuries. Similarly, the patients with CAVI above age-predicted value should be evaluated for risk of falls for prevention of fall-related injuries.

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Section: Main Study Parametersmentioning

confidence: 59%

mentioning

confidence: 98%

<p>Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults</p>

Turusheva¹,

Фролова²,

Kotovskaya³

et al. 2020

VHRM

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“…ИМ и ФП, а его коррекция, напротив, позволяет существенно снизить этот риск [3]. Однако АГ является также одним из ФР развития ССА, снижения уровня физического функционирования, что было показано в предыдущих наших работах [12][13][14].…”

Section: результатыunclassified

“…В пожилом возрасте существует четкая взаимосвязь между степенью жесткости сосудов, ФП, острым нарушением мозгового кровообращения, СД, АГ, систолической АГ, сенсорными дефицитами, уровнем физического функционирования, ско ростью ходьбы, остеопорозом, риском падений и травмами, связанными с падениями. Эта связь описана в предшествующих публикациях [12][13][14]. Ее существованием можно объяснить и более высокий риск развития ИМ у этой категории участников исследования.…”

Section: результатыunclassified

Effect of frailty syndrome on the risk of myocardial infarction and atrial fibrillation

2023

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Aim. To assess the impact of frailty syndrome (FS) on the risk of myocardial infarction (MI) and atrial fibrillation (AF) in people aged ≥65 years.Material and methods. A prospective cohort study of a random sample of a free-living population aged ≥65 years (n=611). Measurement of blood pressure, analysis of therapy, chronic comorbidities, laboratory tests, comprehensive geriatric assessment were performed.Results. FS is associated with an increased risk of MI and AF at 2,5 years of follow-up (odds ratio (OR), 3,195, 95% confidence interval (CI), 1,129-9,042; OR, 1,609, 95% CI, 1,013-2,555, respectively). Additional risk factors for MI and AF were high levels of C-reactive protein, type 2 diabetes, and blood pressure.Conclusion. FS was one of the risk factors for MI and AF during 2,5-year follow-up. Common pathogenetic mechanisms for FS and cardiovascular disease, such as chronic inflammation and insulin resistance, may explain the increased risk of MI and AF in patients with FS. Hypertension retains significance in increasing the risk of MI in patients with FS, which must be taken into account when prescribing antihypertensive therapy. FS screening can be used to assess the risk of cardiovascular events in the elderly and senile age.

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Long-term cardiovascular damage in Leningrad Siege survivors

et al. 2021

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Objective. To assess the prevalence of markers of preclinical vascular, kidney and brain damage in the survivors of the Leningrad Siege (SLS) in the long-term period of life, as well as to determine a possible connection with starvation in the prenatal period and early childhood.Design and methods. A prospective cohort study of 305 SLS was initiated in 2009–2011. In a control sex- and age-matched group we recruited people born in the same time period in other regions of the Soviet Union and permanently residing in Leningrad after the World War II (n = 51). At the second visit in 2013–2014, 252 residents of besieged Leningrad were examined (the response rate was 82,6 %). Blood pressure measurement and anthropometry were performed according to standard methods. The laboratory examination included the assessment of fasting glucose, lipids, and creatinine with the calculation of the glomerular filtration rate (GFR) according to the CKD-EPI formula. The concentration of albumin and creatinine was determined, and the albumin-creatinine ratio was calculated. All patients underwent assessment of the pulse wave velocity by the applanation tonometry (SphygmoCor, AtCor, Australia), cardio-ankle vascular index (CAVI) and ankle-brachial index (VaSera VS 1500, FukudaDenshi, Japan). For cognitive assessment, the Mini-Mental State Examination (MMSE) scale was used.Results. The analysis included data of 184 residents of besieged Leningrad (52 males (28,3 %) and 132 females (71,7 %), average age 74,7 years old) divided into three groups depending on the age period during the Siege: 132 people in the first group (late childhood and adolescents), 28 people in the early childhood group, 24 people in the third “intrauterine” group. The control group included 44 people: 13 males (29,5 %) and 31 females (70,5 %), average age 75,5 years old. The survivors of the besieged Leningrad showed lower anthropometric characteristics — lower weight (p = 0,005) and body mass index (p = 0,004) compared with the control group. There were no differences in the prevalence of vascular, renal and cerebral lesions. The lowest arterial stiffness according to the CAVI index was detected in the “intrauterine” group compared to early, late childhood and adolescent groups (p = 0,015). Renal dysfunction was detected only in the first group (late childhood and adolescents).Conclusions. The residents of the besieged Leningrad demonstrate low prevalence of renal dysfunction and arteriosclerosis of the large arteries and atherosclerosis of the peripheral arteries, as well as preserved cognitive function. The increased arterial stiffness and decreased GFR in SLS who experienced the siege in late childhood and adolescence are most likely due to the older age.

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Validation of cardio-ankle vascular index as a marker of risk of stroke in older adults in St Petersburg and Bashkortostan

Cited by 5 publications

References 15 publications

<p>Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults</p>

<p>Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults</p>

Effect of frailty syndrome on the risk of myocardial infarction and atrial fibrillation

Long-term cardiovascular damage in Leningrad Siege survivors

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