Validation of Cooling Effect of Insulated Containers for the Shipment of Corneal Tissue and Recommendations for Transport

Miller, Thomas D.; Maxwell, Andrew J.; Lindquist, Thomas D.; Requard, Jake

doi:10.1097/ico.0b013e3182685c8e

Cited by 8 publications

(6 citation statements)

References 4 publications

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“…Studies have found that an effective concentration of a single cryopreservative is toxic to CECs, yet the mixture of preservatives or the addition of preservatives at low temperatures seems to reduce toxicity [120]. As a means of corneal preservation, further study is warranted to investigate whether vitrification would achieve good results.…”

Section: Effect Of Corneal Cryopreservationmentioning

confidence: 99%

Cryopreservation in Ophthalmology

Shao¹,

Chen²,

Zhou³

et al. 2020

Cryopreservation - Current Advances and Evaluations

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Amniotic membranes (AMs) and corneas are critical materials in ocular surface reconstruction. AM has specific structures (e.g., basement and two types of cells with stemness characteristics: amniotic epithelial cells and amniotic mesenchymal cells), which contribute to its attractive physical and biological properties that make it fundamental to clinical application. The corneal endothelial cell is a vital part of the cornea, which can influence postoperative vision directly. However, widespread use of fresh AM and cornea has been limited due to their short use span and safety concerns. To overcome these concerns, different preservation methods have been introduced. Cryopreservation is distinguished from many preservation methods for its attractive advantages of prolonged use span, optimally retained tissue structure, and minimized infection risk. This review will focus on recent advances of cryopreserved AM and cornea, including different cryopreservation methods and their indications in ophthalmology.

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Section: Effect Of Corneal Cryopreservationmentioning

confidence: 99%

Cryopreservation in Ophthalmology

Shao¹,

Chen²,

Zhou³

et al. 2020

Cryopreservation - Current Advances and Evaluations

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“…The transportation of tissues depends on the nature of the samples, whether the samples are preserved or live, but also depends on the shipment method, whether this is by air or road transportation [6]. Several published studies have reported the successful transportation of tissues at cooled or frozen conditions using commercially available containers [8,9]. Specifically, in 2013 a study using cornea and blood revealed the maintenance of cooling temperatures during organ shipment [9].…”

Section: Introductionmentioning

confidence: 99%

“…Several published studies have reported the successful transportation of tissues at cooled or frozen conditions using commercially available containers [8,9]. Specifically, in 2013 a study using cornea and blood revealed the maintenance of cooling temperatures during organ shipment [9]. Another study demonstrated the successful shipment of femoral head tissue and Achilles tendon at -40˚C for at least 48 hours indicating that the safety and quality of human tissue could be maintained during transportation at during shipment [8].…”

Section: Introductionmentioning

confidence: 99%

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids

et al. 2020

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The generation of laminated and light responsive retinal organoids from induced pluripotent stem cells (iPSCs) provides a powerful tool for the study of retinal diseases and drug discovery and a robust platform for cell-based therapies. The aim of this study is to investigate whether retinal organoids can retain their morphological and functional characteristics upon storage at room temperature (RT) conditions and shipment by air using a commercially available container that maintains the environment at ambient temperature. Morphological analysis and measurements of neuroepithelial thickness revealed no differences between control, RT incubated and shipped organoids. Similarly immunohistochemical analysis showed no differences in cell type composition and position within the laminated retinal structure. All groups showed a similar response to light, suggesting that the biological function of retinal organoids was not affected by RT storage or shipment. These findings provide an advance in transport of ready-made retinal organoids, increasing their availability to many research and pharma labs worldwide and facilitating cross-collaborative research.

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“…In many developing countries, cultural and religious concerns limit organ donations [ 4 , 5 ]. Furthermore, healthcare and financial restrictions can be a major barrier: for example, a donor cornea from an eye bank in the United States can cost about $3,000 due to the need for microbial testing, administration, and transport alone [ 6 ]. Thus, the lack of human donor tissue at a reasonable cost is one of the largest barriers to reducing blindness through either standard PK or KPro implantation [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities

Cruzat

Tauber

Shukla

et al. 2013

Journal of Ophthalmology

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The Boston keratoprosthesis (B-KPro), currently the most commonly used artificial cornea worldwide, can provide rapid visual rehabilitation for eyes with severe corneal opacities not suitable for standard corneal transplantation. However, the B-KPro presently needs a corneal graft as a tissue carrier. Although corneal allograft tissue is readily available in the United States and other developed countries with established eye banks, the worldwide need vastly exceeds supply. Therefore, a simple, safe, and inexpensive alternative to corneal allografts is desirable for the developing world. We are currently exploring reasonable alternative options such as corneal autografts, xenografts, noncorneal autologous tissues, and laboratory-made tissue constructs, as well as modifications to corneal allografts, such as deep-freezing, glycerol-dehydration, gamma irradiation, and cross-linking. These alternative tissue carriers for the B-KPro are discussed with special regard to safety, practicality, and cost for the developing world.

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Validation of Cooling Effect of Insulated Containers for the Shipment of Corneal Tissue and Recommendations for Transport

Cited by 8 publications

References 4 publications

Cryopreservation in Ophthalmology

Cryopreservation in Ophthalmology

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids

Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities

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