Validation of Corrected and Dispersed QT as Predictors of Adverse Outcomes in Acute Cardiotoxicities

El-Sarnagawy, Ghada N; Shaban, Aliaa; Lashin, Heba

doi:10.1007/s12012-020-09629-8

Cited by 14 publications

(1 citation statement)

References 60 publications

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“…Meanwhile, our study revealed that HR (OR = 1.035, 95%CI 1.026 ~ 1.044) and QTc (OR = 1.013, 95%CI 1.007 ~ 1.019) were the independent risk factors for predicting poor prognosis in poisoned patients. A report con rmed that QTc can be used as a predictor of the adverse outcomes in acute poisoning [24]. Likewise, another study demonstrated that ECG can be used as an indicator of cardiovascular prognosis in patients with acute drug poisoning [25].…”

Section: Discussionmentioning

confidence: 97%

Early Predictive Value of the Electrocardiogram Combined with Q-SOFA Score for the Prognosis of Acute Poisoning Patients: A Retrospective Analysis

Yin

et al. 2022

Preprint

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Background: Acute poisoning is a worldwide and frequently occurring disease, endangering millions of people and leading to ten thousands of deaths every year. Early effective evaluation and appropriate treatment are the key to improve the clinical outcomes. However, early accurate assessment of the conditions in patients with acute poisoning is challenging. This study aimed to investigate the utility of electrocardiogram (ECG) combined with quick Sequential Organ Failure Assessment (q-SOFA) score as early prognostic predictors in acute poisoning patients. Methods: The clinical data of acute poisoning patients were collected from 2016 to 2022 in a regional medical center. The statistical analysis was used to evaluate the risk factors related to prognosis based on their ECG. And the receiver operating characteristic (ROC) curve were used to evaluate the early diagnostic value of ECG combined with q-SOFA. Results: Among the 572 patients, 119 patients belonged to the survived group and 453 patients belonged to the died. ECG abnormalities were detected in 71.3% of survivors and 88.2% of dead (p＜0.05). One variable analysis revealed that heart rate (HR), ECG axis, PR intervals, RV5, R+S, and ST-T change (all p＜0.05) of ECG had significant differences in the prognosis of patients between two groups. Multifactorial logistic results showed that HR (OR=1.035, 95%CI 1.026~1.044) and QTc (OR=1.013, 95%CI 1.007~1.019) were independent risk factors for death. ROC curve analysis revealed that the area under the cure (AUC) of ECG was 0.777 (95%CI 0.728~0.827), q-SOFA score was 0.736 (95%CI 0.684~0.787), PSS score was 0.617 (95%CI 0.558~0.677), and the prediction model constructed based on HR, QTc and q-SOFA score was 0.808 (95%CI 0.763~0.852), with the best diagnostic accuracy (50.4%). Conclusion: ECG combined with q-SOFA is a useful early predictor of poor outcome in acute poisoning patients. It has better accuracy and certain feasibility compared with PSS score.

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Section: Discussionmentioning

confidence: 97%

Early Predictive Value of the Electrocardiogram Combined with Q-SOFA Score for the Prognosis of Acute Poisoning Patients: A Retrospective Analysis

Yin

et al. 2022

Preprint

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Comparison between various scoring systems in predicting the need for intensive care unit admission of acute pesticide-poisoned patients

El-Sarnagawy

Abdelnoor

Abuelfadl

et al. 2022

Environ Sci Pollut Res

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Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes

El-Sarnagawy

Ghonem

Abdelhameid

et al. 2022

Environ Sci Pollut Res

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Paraphenylenediamine (PPD) is a commonly used xenobiotic in hair dying, causing deleterious outcomes in acute poisoning. Although many epidemiological studies and case reports explained their clinical presentations and fatal consequences, no studies have evaluated the early determinants of adverse outcomes. Therefore, the present study aimed to assess the initial predictors of acute PPD poisoning adverse outcomes, focusing on the discriminatory accuracy of the Rapid Emergency Medicine Score (REMS) and Sequential Organ Failure Assessment (SOFA) score. A retrospective cohort study included all acute PPD-poisoned patients admitted to three Egyptian emergency hospitals from January 2020 to January 2022. Data was gathered on admission, including demographics, toxicological, clinical, scoring systems, and laboratory investigations. Patients were categorized according to their outcomes (mortality and complications). Ninety-seven patients with acute PPD poisoning were included, with a median age of 23 years, female predominance (60.8%), and suicidal intention (95.9%). Out of all patients, 25.77% died, and 43.29% had complicated outcomes. Respiratory failure was the primary cause of fatalities (10.30%), while acute renal failure (38.14%) was a chief cause of complications. The delay time till hospitalization, abnormal electrocardiogram, initial creatine phosphokinase, bicarbonate level, REMS, and SOFA scores were the significant determinants for adverse outcomes. The REMS exhibited the highest odds ratio (OR = 1.91 [95% confidence interval (CI): 1.41–2.60], p < 0.001) and had the best discriminatory power with the area under the curve (AUC) = 0.918 and overall accuracy of 91.8% in predicting mortality. However, the SOFA score had the highest odds ratio (OR = 4.97 [95% CI: 1.16–21.21], p = 0.001) and only yielded a significant prediction for complicated sequels with AUC = 0.913 and overall accuracy of 84.7%. The REMS is a simple clinical score that accurately predicts mortality, whereas the SOFA score is more practicable for anticipating complications in acute PPD-poisoned patients.

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Validation of Corrected and Dispersed QT as Predictors of Adverse Outcomes in Acute Cardiotoxicities

Cited by 14 publications

References 60 publications

Early Predictive Value of the Electrocardiogram Combined with Q-SOFA Score for the Prognosis of Acute Poisoning Patients: A Retrospective Analysis

Early Predictive Value of the Electrocardiogram Combined with Q-SOFA Score for the Prognosis of Acute Poisoning Patients: A Retrospective Analysis

Comparison between various scoring systems in predicting the need for intensive care unit admission of acute pesticide-poisoned patients

Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes

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