Validation of cutaneous lymphoma international prognostic index (CLIPI) for mycosis fungoides and Sézary syndrome

Danish, H.; Liu, Shilin; Jhaveri, Jaymin; Flowers, Christopher R.; Lechowicz, Mary Jo; Esiashvili, Natia

doi:10.3109/10428194.2016.1173210

Cited by 19 publications

(38 citation statements)

References 22 publications

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“…Predictors of poor survival were advanced age, male sex, and stage >IB. Our study supports the previous literature, which suggests that advanced age and male sex are associated with poor survival [2,5,[13][14][15][16] . This is in keeping with the cutaneous lymphoma international prognostic index (CLIPi) for MF and SS, which lists male gender and age >60 as significant adverse prognostic factors [17] .…”

Section: Discussionsupporting

confidence: 82%

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Giberson

Mourad²,

Gniadecki³

2017

Dermatology

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Background: Folliculotropic mycosis fungoides (FMF) is a distinct subtype of mycosis fungoides (MF) with unique clinicopathological features. The medical literature suggests that FMF has a more aggressive course and worse survival than classic MF. Previous studies do not use standardized treatment, and no studies have reported an association between treatment response and overall survival (OS). Objective: To compare OS for MF, FMF, and Sézary syndrome (SS) patients. Methods: Data were collected retrospectively from 218 patients (171 MF, 15 SS, 32 FMF) treated in a single academic center between 1970 and 2016. Results: Negative predictors of OS were age (OR = 1.07), male sex (OR = 1.63), and stage IIB, III, and IV (OR = 4.10, 5.42, and 7.54, respectively, vs. stage IA). Lack of initial PUVA response was strongly associated with negative OS (OR = 3.08). Kaplan-Meier analysis of age-, sex-, and stage-matched MF and FMF patients found similar OS between the 2 groups. The 5-year OS was 91% for FMF and 74% for MF. Meta-analysis of current data and 2 published studies where survival of FMF patients was compared to MF did not reveal statistically significant differences between these 2 diseases. Conclusions: When patients were matched for age, sex, and disease stage, folliculotropism did not affect OS in MF.

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Section: Discussionsupporting

confidence: 82%

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Giberson

Mourad²,

Gniadecki³

2017

Dermatology

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“…The authors considered that the score had a good performance in terms of risk stratification for early stage MF patients, and as Benton et al, suggested its validation in appropriate prospective studies. 17 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides

Amorim

Corbellini

Quintella

et al. 2018

An. Bras. Dermatol.

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BackgroundMycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed.ObjectiveTo evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF.MethodsThis is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death.ResultsOne hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification.Study LimitationsSmall sample and its retrospective analysis.ConclusionsSince CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.

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“…With regard to serum LDH, it is known that this parameter has prognostic potential in CTCL. Several studies showed that elevated LDH is an indicator for worse outcome in CTCL patients . Unlike Dicer expression, however, Drosha expression has never been studied in the above‐mentioned context.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies showed that elevated LDH is an indicator for worse outcome in CTCL patients. 3,15 Unlike Dicer expression, 9 however, Drosha expression has never been studied in the above-mentioned context. Gelmez et al 16 recently demonstrated that advanced-stage patients with chronic lymphocytic leukaemia showed decreased Dicer and Drosha expression.…”

Section: Discussionmentioning

confidence: 99%

Low Drosha protein expression in cutaneous T‐cell lymphoma is associated with worse disease outcome

Gambichler

Salveridou

Schmitz

et al. 2019

Acad Dermatol Venereol

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Background Dysregulation of microRNAs (miRNAs) key regulators may contribute to the pathogenesis of malignancies. miRNA machinery genes such Dicer and Drosha have been reported to be biomarkers in different cancer types. Objectives We aimed to evaluate Drosha and Dicer protein expression in cutaneous T‐cell lymphoma (CTCL). Methods We performed Drosha and Dicer immunohistochemistry in 45 patients with mycosis fungoides and subtypes. Drosha and Dicer expression scores were correlated with clinical parameters including disease‐specific death (DSD), stage of disease and different laboratory data. Uni‐ and multivariate statistics were performed. Results On univariate analysis, elevated serum LDH and low Drosha expression were significantly associated with advanced stage (P = 0.032 and 0.0062, respectively) and lymphoma‐specific death (LSD; P = 0.017 and P = 0.005, respectively). Moreover, elevated circulating CD4+/CD26− lymphocytes were significantly associated with advanced stage (P = 0.032) and DSD (P = 0.0098). On multivariate analysis, low Drosha expression remained in the logistic regression model as significant independent predictor for advanced disease stages [P = 0.013; odds ratio: 5 (confidence interval) CI 1.3–19.3]. Moreover, low Drosha expression (P = 0.026) and elevated LDH (P = 0.025) remained as significant independent predictors for DSD with odds ratios of 13.5 (CI 1.3–134.4 and 8.7 CI 1.3–57.2, respectively). Conclusions Low Drosha expression is an independent predictor for advanced stage as well as LSD in CTCL patients indicating a tumour suppressor gene function of Drosha in this disorder.

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Validation of cutaneous lymphoma international prognostic index (CLIPI) for mycosis fungoides and Sézary syndrome

Cited by 19 publications

References 22 publications

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides

Low Drosha protein expression in cutaneous T‐cell lymphoma is associated with worse disease outcome

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