Validation of daily urinary creatinine excretion measurement by muscle‐creatinine equivalence

Iacone, Roberto; D’Elia, Lanfranco; Guida, Bruna; Barbato, Antonio; Scanzano, C.; Strazzullo, Pasquale

doi:10.1002/jcla.22407

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Additionally, some studies have attempted to mitigate the effects of urine volume on UIC by adjusting for urinary creatinine concentration [ 19 , 20 ]. Nevertheless, factors such as age, ethnicity, skeletal muscle content, and protein intake can all affect urinary creatinine concentration [ 21 , 22 ]. Therefore, there remains significant controversy over the use of creatinine-adjusted UIC to assess individual iodine nutritional status.…”

Section: Discussionmentioning

confidence: 99%

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Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China

et al. 2023

Nutrients

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Iodine deficiency during pregnancy is a widespread public health concern, but indicators and methods for assessing iodine nutritional status are lacking. Serum iodine concentration (SIC) is an important iodine metabolism biomarker and can, to some extent, predict the risk of thyroid diseases, making it a potential biomarker for assessing individual iodine nutrition levels. Our study aimed to analyze the relationship between SIC and thyroid function in a cohort of mild iodine deficient pregnant women in China in order to explore the potential of SIC as a biomarker of individual iodine status in pregnancy. A total of 1540 early pregnant women (gestation < 10 weeks) aged 18 to 45 years old were included in the final study from a Zhejiang multicenter population-based mother and child cohort. Repeated measures of SIC, urinary iodine concentration (UIC), and thyroid function were taken at approximately 10, 17, and 32 weeks of gestation. The SIC was statistically correlated with all thyroid function indexes in the first trimester, and a very strong positive correlation with FT4 over three trimesters (r = 0.449, 0.550, and 0.544, respectively). Pregnant women with an SIC < 72.4 µg/L were at a higher risk of hypothyroxinemia (adjusted OR = 8.911, 95% CI = 5.141–15.447) and iodine deficiency (adjusted OR = 1.244, 95% CI = 1.031–1.502), while those with an SIC > 93.9 µg/L were at a higher risk of thyrotoxicosis (adjusted OR = 11.064, 95% CI = 6.324–19.357) and excessive iodine (adjusted OR = 11.064, 95% CI = 6.324–19.357). In contrast, the UIC was not correlated with thyroid diseases (p > 0.05). These findings indicate that the SIC is a potential biomarker for assessing individual iodine nutrition and thyroid dysfunction in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China

et al. 2023

Nutrients

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show abstract

“…In addition, some studies have attempted to mitigate the effect of urine output on UIC by adjusting for urinary creatinine concentration (5,32). However, factors such as age, ethnicity, skeletal muscle content, and protein intake can affect urinary creatinine concentration (33,34). Therefore, the use of creatinine-adjusted UIC to assess individual iodine nutritional status remains highly controversial.…”

Section: Discussionmentioning

confidence: 99%

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Ji,

Wu,

et al. 2023

Front. Endocrinol.

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BackgroundIodine deficiency is a major public health problem in pregnant women. Serum iodine (SI) may represent a useful biomarker for iodine nutrition evaluation. We aimed to assess the relationship between serum iodine concentration (SIC) and urinary iodine concentration (UIC), dietary iodine, thyroid function, and thyroid diseases in pregnant women in the southeast coast of China, and to provide a normal reference range of SIC for pregnant women.MethodsA multistage random sampling method was used to select the study population. We collected urine and blood samples from pregnant women and determined UIC and SIC as well as thyroid function using Arsenic-Cerium Catalytic Spectrophotometry, inductively coupled plasma mass spectrometry, and Beckman Coulter Access2 chemiluminescent immunoanalyzer and kit, respectively, and administered a questionnaire on dietary iodine intake in pregnant women.ResultsThere was a significant negative correlation between SI and thyroid-stimulating hormone (TSH) (r = −0.141) and a significant positive correlation between SI and free triiodothyronine (FT3) (r = 0.106), free thyroxine (FT4) (r = 0.236), triiodothyronine (TT3) (r = 0.229), total thyroxine (TT4) (r = 0.433), and dietary iodine intake (r = 0.068). There was a significant difference in SI levels of pregnancy between the second (78.13 μg/L) and third trimester (75.37 μg/L) (p = 0.018). SI levels between inadequate intake (74.58 μg/L) and appropriate intake (77.92 μg/L) groups were statistically different (p = 0.036). Low SIC was a risk factor for the development of hypothyroxinemia (adjusted OR = 3.14, 95% confidence interval: 1.75–5.66). The reference range for SIC in normal pregnant women is 45.03–112.44 μg/L.ConclusionSI may be a composite indicator of iodine nutritional status and thyroid function.

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“…Moreover, if an athlete had participated in sports sessions in the last seven days or if patients were using diuretics, we excluded them (n = 7). In addition, individuals who did not collect urine more than twice in the 24-h urine collection period and those whose measurement was less than 500 mL/24 h were excluded (n = 19) from the study [ 19 ]. A total of 310 participants were included in the current analysis.…”

Section: Methodsmentioning

confidence: 99%

Handgrip Strength Is Positively Associated with 24-hour Urine Creatine Concentration

Ulambayar

Bor

Sukhbaatar³

et al. 2023

IJERPH

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Background: Muscle mass evaluation methods are often expensive and therefore limited in their daily use in clinical practice. In this study, we investigated the relationship between hand grip strength (HGS) and other parameters of body measurements with urine creatinine, especially to investigate whether HGS measurement is an indicator of muscle metabolism. Methods: In total, 310 relatively healthy people (mean age 47.8 + 9.6; 161 people or 51.9% of the total population were men) who were undergoing preventive examinations were included in this study and given a container to collect 24-h urine, and the amount of creatinine in the urine was determined by a kinetic test without deproteinization according to the Jaffe method. A digital dynamometer (Takei Hand Grip Dynamometer, Japan) was used in the measurement of HGS. Results: There was a significant difference in 24-h urine creatinine (24 hCER) between the sexes, with a mean of 1382.9 mg/24 h in men and 960.3 mg/24 h in women. According to the correlation analysis, the amount of urine creatinine was related to age (r = −0.307, p < 0.001 in men, r = −0.309, p < 0.001 in women), and HGS (r = 0.207, p = 0.011 in men, r = 0.273, p = 0.002 in women) was significant for either sex. However, other parameters of body measurements, such as girth, forearm circumference, and muscle mass measured by bioelectrical impedance, were not related to urine 24 hCER. A correlation between HGS and 24 hCER was observed in age groups. Conclusions: We found that HGS is a potential marker in muscle metabolism assessment that is proven through 24 hCER. In addition, therefore, we suggest using the HGS measure in clinical practice to evaluate muscle function and well-being.

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Validation of daily urinary creatinine excretion measurement by muscle‐creatinine equivalence

Cited by 7 publications

References 16 publications

Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China

Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Handgrip Strength Is Positively Associated with 24-hour Urine Creatine Concentration

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