Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid

Hsu, Derek Y.; Brieva, Joaquin C.; Nardone, Beatrice; Silverberg, Jonathan I.

doi:10.1111/bjd.14172

Cited by 34 publications

(30 citation statements)

References 6 publications

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“…In contrast, previous studies of hospitalization and mortality in BP were limited to more homogeneous patient populations, small sample sizes, and tertiary‐care centres or small regional hospitals, which may not be generalizable to the entire population. We previously validated the ICD‐9‐CM code for BP and found it to have excellent specificity and positive predictive value in the inpatient setting . Nevertheless, it is possible that some other cases of bullous disease are misclassified as BP.…”

Section: Discussionmentioning

confidence: 99%

“…We previously validated the ICD-9-CM code for BP and found it to have excellent specificity and positive predictive value in the inpatient setting. 8 Nevertheless, it is possible that some other cases of bullous disease are misclassified as BP. In addition, we corrected P-values to address concerns of multiple statistical testing.…”

Section: Discussionmentioning

confidence: 99%

“…The primary diagnosis was defined in NIS as the condition chiefly responsible for admission to the hospital for care. A previous study validated the use of a single ICD‐9‐CM code of 694.5 in the inpatient setting for the study of BP . Patients with ICD‐9‐CM diagnostic codes of both 694.5 and 694.4 (pemphigus) were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…A previous study validated the use of a single ICD-9-CM code of 694.5 in the inpatient setting for the study of BP. 8 Patients with ICD-9-CM diagnostic codes of both 694.5 and 694.4 (pemphigus) were excluded.…”

Section: Identification Of Bullous Pemphigoidmentioning

confidence: 99%

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Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A.

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Identification Of Bullous Pemphigoidmentioning

confidence: 99%

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Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A.

et al. 2016

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“…1 Given that our understanding of PG is limited by disease rarity and considerable misdiagnosis rates (~30-50%), 2 establishing a method to identify cases in large databases would facilitate population-based research. This approach has been used in other dermatological diseases, [3][4][5] where case identification is performed by diagnosis-related queries based on the International Classification of Diseases (ICD) code. However, this method is unreliable, leading to inaccurate diagnoses, missing and/or incomplete data and misclassification bias.…”

mentioning

confidence: 99%

The validity of the diagnostic code for pyoderma gangrenosum in an electronic database

Lockwood

Butler

et al. 2018

Br J Dermatol

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Costs of Care for Hospitalization for Pemphigus in the United States

2016

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IMPORTANCE Pemphigus is an autoimmune blistering disorder associated with significant morbidity and mortality. However, little is known about the inpatient burden of pemphigus. OBJECTIVE To determine the incidence of and risk factors for hospitalization with pemphigus and cost of care. DESIGN, SETTING, AND PARTICIPANTSThe 2002-2012 Nationwide Inpatient Sample provided by the Healthcare Cost and Utilization Project from the Agency for Healthcare Research and Quality was analyzed. A total of 87 039 711 children and adults (mean [SD] age, 57.7 [0.98] years for those with a primary diagnosis of pemphigus; 70.6 [0.32] years for those with a secondary diagnosis of pemphigus; and 47.9 [0.19] years for those without a diagnosis of pemphigus) were studied. Data analysis was performed from June 1 to August 30, 2015. MAIN OUTCOMES AND MEASURES Hospitalization rates, length of stay, and cost of care. RESULTS There were 1185 and 5221 patients admitted with a primary or secondary diagnosis of pemphigus, respectively; when factoring in weights that generalize the sample to the entire hospitalized US cohort, these admissions represented weighted frequencies of 5647 and 24 880, respectively. In multivariable logistic regression models with stepwise selection, increasing age (adjusted odds ratios [95% CIs]: 18-39 years: 5.53 [4.28-7.14], P < .001; 40-59 years: 10.98 [8.46-14.24], P < .001; 60-79 years: 7.54 [5.75-9.89], P < .001; Ն80 years: 7.57 [5.71-10.04], P < .001), female sex (1.10 [1.01-1.20], P = .047), nonwhite race/ethnicity (black: 1.94 [1.75-2.14], P < .001; Hispanic: 4.10 [3.74-4.48], P < .001; Asian: 3.16 [2.68-3.73], P < .001; Native American: 2.11 [1.45-3.08], P < .001), lower household income (quartile 2: 1.19 [1.07-1.32], P < .001), being insured with Medicare (1.56 [1.41-1.74], P < .001) or Medicaid (1.55 [1.39-1.73], P < .001), number of chronic conditions (2-5: 2.36 [2.10-2.65], P < .001; Ն6: 1.47 [1.29-1.69], P < .001), hospital location in a metropolitan area (not metropolitan or micropolitan: 0.60 [0.49-0.72], P < .001), and summer season (1.12 [1.02-1.23], P = .02) were all associated with hospitalization for pemphigus. The total inflation-adjusted cost of care for patients with a primary inpatient diagnosis of pemphigus was $74 466 305, with a mean (SD) annual cost of $14 520.93 ($913.22). The inflation-adjusted cost of care for patients with a primary diagnosis of pemphigus increased significantly from 2002 to 2012 (analysis of variance, P < .001). In particular, length of stay was higher in racial/ethnic minorities compared with whites (survey linear regression, log β [95% CI]: black: 0.076 [0.075-0.076]; Hispanic: 0.021 [0.021-0.022]; Asian: 0.037 [0.036-0.039]; Native American: 0.010 [0.0076-0.013]), lower quartile household income (quartile 1: 0.024 [0.023-0.024]; quartile 2: 0.0029 [0.0022-0.0035]), and those without private insurance (Medicare: 0.12 [0.12-0.12]; Medicaid: 0.082 [0.081-0.083]; no charge: 0.051 [0.047-0.055]). CONCLUSIONS AND RELEVANCE There is a significant inpatient burden for pemp...

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Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid

Cited by 34 publications

References 6 publications

Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A.

Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A.

The validity of the diagnostic code for pyoderma gangrenosum in an electronic database

Costs of Care for Hospitalization for Pemphigus in the United States

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