Validation of Dermoscopy as a Real-time Noninvasive Diagnostic Imaging Technique for Actinic Keratosis

Huerta-Brogeras, María; Olmos, Olga; Borbujo, J.; Hernández‐Núñez, A.; Castaño, Esther; Romero‐Maté, Alberto; Martínez-Sánchez, Diego; Martínez‐Morán, C.

doi:10.1001/archdermatol.2012.1060

Cited by 69 publications

(60 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…). The features most consistently found with dermoscopy of AK lesions are the erythematous pseudonetwork and follicular openings …”

Section: Dermoscopymentioning

confidence: 91%

A new vision of actinic keratosis beyond visible clinical lesions

Malvehy

2014

Acad Dermatol Venereol

View full text Add to dashboard Cite

In actinic keratosis (AK), clinical and subclinical lesions coexist across large areas of sun-exposed skin resulting in field cancerization. The lesions are part of a disease continuum which can progress into invasive squamous cell carcinoma (SCC). Conventional biopsy sampling together with histopathological analysis of the excised tissue is still the gold standard for differentially diagnosing AK from invasive SCC and identifying the characteristic pathophysiological features of these lesions. Given that biopsy sampling is invasive and not suited to the investigation of disease across large fields of skin, several imaging technologies have been applied to non-invasively investigate AK. Widely available imaging technologies such as cross-polarized light, fluorescence and dermoscopy can assist the dermatologist in diagnosing AK and in identifying different types of AK lesions. Modern imaging technologies such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) provide high-resolution images of the skin. These techniques can be used to image the histological changes that characterize AK and so can be used to diagnose the disease and its severity. They can also identify the presence of subclinical lesions and non-invasively monitor the effects of AK treatments on both subclinical and clinical lesions over time. Both RCM and HD-OCT have revealed a new vision of AK by visualizing in detail the cellular and histological changes that characterize both clinical and subclinical lesions, and confirming that the disease affects the entire sun-exposed field. As a consequence of these findings, the target for the treatment of AK now needs to be the detection and clearance of all clinical and subclinical lesions across the entire sun-exposed field.

show abstract

“…). The features most consistently found with dermoscopy of AK lesions are the erythematous pseudonetwork and follicular openings …”

Section: Dermoscopymentioning

confidence: 91%

A new vision of actinic keratosis beyond visible clinical lesions

Malvehy

2014

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…In elderly patients with clear evidence of photodamaged skin, physicians should check for the presence of AK in sun-exposed areas, irrespective of the reason for the consultation. Dermoscopy improves the clinical diagnosis of AK and has been reported to reach a 98.7% and 95.0% diagnostic sensitivity and specificity, respectively (23).…”

Section: Ak Diagnosismentioning

confidence: 99%

“…Depending on the clinical aspects, dermoscopy reveals either a red network pattern (grade 1), a "strawberry pattern" (grade 2), or structureless white to yellow areas (grade 3) (Figure 2) (23,24). Moreover, dermoscopy can aid in the assessment of treatment response ( Figure 3) and in the differential diagnosis of AK versus other benign non-melanocytic lesions such as solar lentigo or seborrheic keratosis.…”

Section: Ak Diagnosismentioning

confidence: 99%

Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Dirschka

Gupta

Micali

et al. 2016

Journal of Dermatological Treatment

View full text Add to dashboard Cite

Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology. areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.

show abstract

“…With regard to this issue, lessons may be taken from studies on nonpigmented facial actinic keratosis (AK). In detail, erythema, scaling and follicular changes such as whitening, unequal size and enlargement due to keratotic plugs (targetoid follicles) are key dermoscopic features, allowing the clinician to diagnose nonpigmented facial AK with a sensitivity of 98·7% and a specificity of 95·0% …”

mentioning

confidence: 99%

Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis

et al. 2016

View full text Add to dashboard Cite

show abstract

Validation of Dermoscopy as a Real-time Noninvasive Diagnostic Imaging Technique for Actinic Keratosis

Abstract: To validate dermoscopy as a real-time noninvasive diagnostic imaging technique for actinic keratosis (AK).

Cited by 69 publications

References 25 publications

A new vision of actinic keratosis beyond visible clinical lesions

A new vision of actinic keratosis beyond visible clinical lesions

Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis

Contact Info

Product

Resources

About