Validation of determination of lead (Pb) in blood by electrothermal atomic absorption spectrometry (ETAAS) on the basis of interlaboratory comparison data

Working Towards Accreditation by the International Standards Organization 15189 Standard: How to Validate an In-house Developed Method an Example of Lead Determination in Whole Blood by Electrothermal Atomic Absorption Spectrometry

“…The lower limit of quantification (LLOQ) was fixed at 10 µg/L. According to published data, a LLOQ between 10 and 15 µg/L was considered normal [ 12 , 13 , 14 , 15 ].…”

“…Intra-assay and inter-assay imprecision were evaluated as requested by French regulation authorities, and were less than 10% [ 12 ]. It was also possible to compare the performances of the method to published data or proficiency test results [ 13 , 14 , 15 ]. On the contrary, biological imprecision criteria published by Vassault et al [ 16 ] and Minchinela et al [ 17 ] could not be used, as exogenous substances like lead were not included in their databases.…”