Validation of electrohysterography for uterine peristalsis in non-pregnant uteri

Kuijsters, N.P.; Methorst, W.G.; Kortenhorst, Madeleine S.Q.; Santini, M; Rabotti, C.; Schoot, Benedictus C.

doi:10.1016/j.fertnstert.2013.07.726

Cited by 3 publications

(2 citation statements)

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“…Histological and in-vitro tests with freshly harvested uteri would be necessary approaches, although EHG could answer some questions in vivo as well. EHG would make it possible to identify pacemaker regions and explore which regions are electrically most active in which phases of the cycle (Kuijsters et al, 2013;Rabotti et al, 2008). As an aid in this research direction, it is possible to show this activity in coloured heat maps to make it easier to identify these regions (Figure 16).…”

Section: Discussionmentioning

confidence: 99%

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Kuijsters

Methorst

Kortenhorst

et al. 2017

Reproductive BioMedicine Online

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Although uterine contractions in the non-pregnant uterus have been studied extensively, the knowledge gained has not been used in general fertility treatment work-up. In this review paper, we provide an overview of the current knowledge on uterine peristalsis (UP), based on the available literature. This literature shows that UP influences pregnancy chances in both natural and artificial cycles. Although the physiological background of these contractions is not completely clear, we know that several factors can be of influence, like uterine pathologies and hormones. Several options to alter pregnancy outcome by interfering with uterine contractions have been studied. Our meta-analysis on therapeutic options shows positive results of progesterone at time of embryo transfer in IVF cycles or prostaglandins at time of intrauterine insemination, although the quality of evidence is low. These therapies are probably most beneficial in selected groups of patients with abnormal contraction patterns. The introduction of an objective and user-friendly UP measuring tool suitable for use in daily practice would make it possible to identify and monitor these patients. We suggest that future research should focus on the physiology of initiation of UP and on the development of an effective standard measuring tool.

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Section: Discussionmentioning

confidence: 99%

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Kuijsters

Methorst

Kortenhorst

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

“…Most research on the menstrual cycle has focused on hormones and their effects on the epithelium. However, some evidence indicates that the smooth muscle layer, the myometrium, also contributes to uterine functions by generating slow, low-magnitude, spontaneous contractions, termed uterine peristalsis [1][2][3][4][5][6][7][8][9][10] . Unlike labor contractions, in which the entire myometrium produces faster and stronger contractions, uterine peristalsis only involves the inner layer of the myometrium, the stratum subvasculare.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive electrophysiological imaging identifies 4D uterine peristalsis patterns in subjects with normal menstrual cycles and patients with endometriosis

Wang

Anderson

Pizzella

et al. 2023

Preprint

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Throughout the menstrual cycle, spontaneous mild contractions in the inner layer of the uterine smooth muscle cause uterine peristalsis, which plays a critical role in normal menstruation and fertility. Disruptions in peristalsis patterns may occur in women experiencing subfertility, abnormal uterine bleeding, ovulatory dysfunction, endometriosis, and other disorders. However, current tools to measure uterine peristalsis in humans have limitations that hamper their research or clinical utilities. Here, we describe an electrophysiological imaging system to noninvasively quantify the four-dimensional (4D) electrical activation pattern during human uterine peristalsis with high spatial and temporal resolution and coverage. We longitudinally imaged 4968 uterine peristalses in 17 participants with normal gynecologic anatomy and physiology over 34 hours and 679 peristalses in 5 participants with endometriosis over 12.5 hours throughout the menstrual cycle. Our data provide quantitative evidence that uterine peristalsis changes in frequency, direction, duration, magnitude, and power throughout the menstrual cycle and is disrupted in endometriosis patients. Moreover, our data suggest that disrupted uterine peristalsis contributes to excess retrograde menstruation and infertility in patients with endometriosis and potentially contributes to infertility in this cohort.

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Noninvasive imaging of 4D electrical activation patterns of uterine peristalsis during normal menstrual cycles

Wang,

Anderson,

Pizzella

et al. 2024

npj Womens Health

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Uterine peristalsis, characterized by spontaneous slow-wave contractions of the subendometrial layer of the uterine myometrium, occurs throughout the menstrual cycle. Disruptions in peristalsis patterns may occur in women experiencing abnormal uterine bleeding, endometriosis, and infertility. Current tools to measure uterine peristalsis in humans have limitations that hamper their research or clinical utility. Here, we developed an electrophysiological imaging system with wearable electrical sensors to noninvasively quantify the four-dimensional electrical activation pattern during human uterine peristalsis with high spatial and temporal resolution and coverage. To demonstrate capabilities of this new imaging system, we enrolled 26 pre-menopausal participants ages 18–40 years old with regular menstrual cycles (25–34 days in length) and normal gynecologic anatomy. Participants initially underwent magnetic resonance imaging to obtain the body-uterus geometry. Then, during each of the four phases of a single menstrual cycle, patients underwent noninvasive electrical recording for 30 min. We measured uterine peristalsis frequency, direction, duration, magnitude, and power and found that these parameters differed in different phases of the menstrual cycle. Future use of this uterine peristalsis imaging system may advance our understanding of the role of uterine peristalsis in maintaining normal uterine function and contributing to gynecological pathophysiology.

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Validation of electrohysterography for uterine peristalsis in non-pregnant uteri

Cited by 3 publications

References 0 publications

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Noninvasive electrophysiological imaging identifies 4D uterine peristalsis patterns in subjects with normal menstrual cycles and patients with endometriosis

Noninvasive imaging of 4D electrical activation patterns of uterine peristalsis during normal menstrual cycles

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