Validation of ethnopharmacology of ayurvedic sarasvata ghrita and comparative evaluation of its neuroprotective effect with modern alcoholic and lipid based extracts in β-amyloid induced memory impairment

Beneficial effects of two Ayurvedic formulations, Saraswata Ghrita and Kalyanaka Ghrita on survival and on toxic aggregates in Drosophila models of Huntington’s and Alzheimer’s disease

“…Based on an in-vitro study (Mamidala et al, 2016) on the IMR 32 human neuroblastoma cell line, SG was suggested as an effective treatment for ASD (Autism Spectrum Disorder) as it enhanced levels of serotonin, Dopamine and Gamma-aminobutyric acid. In another study (Shelar et al, 2018), SG and its lipid extract were found to be effective in reducing Aβ plaques, improve memory and enhance levels of superoxide dismutase, glutathione peroxidase, chloramphenicol acetyltransferase and nitrous oxide in rat model; interestingly, the lipid extract was found to be more effective than ethanolic extract of SG. There does not seem to be any effective experimental study that has examined effects of KG or its various component herbs in in vitro or in vivo models.…”

Health benefits of ghee: Review of Ayurveda and modern science perspectives

“…Similarly, Jyotismati oil along with ghee showed significant enhancement in spatial and fear memory in rats [ 45 ]. Sarasvata Ghrita exhibits neuroprotective activity by reducing malondialdehyde levels, increasing antioxidant enzyme levels, inhibiting acetylcholinesterase activity, and promoting the release of brain-derived neurotrophic factor [ 46 ]. Kushmanda Ghrita significantly improved the psychometric parameters and clinical symptoms in clinically diagnosed cases of depressive illness [ 47 ].…”