Research was conducted in North Carolina to determine interactions of irrigation and fungicide program on canopy defoliation caused by early leaf spot (Cercospora arachidicolaHori) and web blotch (Phoma arachidicola Marasas et al.), pod yield, and percentages of extra large kernels (%ELK), fancy pods (%FP), and total sound mature kernels (%TSMK) for the Virginia market type peanut cultivar Gregory. Irrigation treatments included no irrigation, subsurface drip irrigation (SDI), overhead sprinkler irrigation (OSI), and a combination of SDI and OSI. Fungicide programs included no fungicide or bi‐weekly applications beginning in early July through mid‐September. Bi‐weekly fungicide applications decreased canopy defoliation (P≤ 0.0001), increased pod yield (P≤ 0.0001), %ELK (P≤ 0.0001), and %FP (P= 0.0166) but did not affect %TSMK (P= 0.1603) when compared with the no‐fungicide control. Irrigation did not affect canopy defoliation (P= 0.3788) but did affect pod yield (P= 0.0878), %ELK (P= 0.0021), %FP (P= 0.0031), and %TSMK (P= 0.0702). The %ELK was similar when peanut was not irrigated (48%) or was irrigated with SDI only (46%) and the combination of SDI and OSI (48%). The highest %ELK was noted when with OSI only (52%). Irrigation increased %FP regardless of irrigation system compared with non‐irrigated peanut (84% versus 87 to 90%).