Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD-Specific Metric

Rapoport, Yuna; Freeman, Thomas H.; Koyama, Tatsuki; Engelhardt, Brian G.; Jagasia, Madan; Savani, Bipin N.; Tran, Uyen; Kassim, Adetola A.

doi:10.1097/ico.0000000000001109

Cited by 37 publications

(24 citation statements)

References 25 publications

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“…65 Those subjective and objective variables are used worldwide for diagnosing dry eye. Three studies from ours and other institutes validated the newly proposed criteria and showed good agreement between the international chronic ocular GVHD Consensus Group scores (ICOS) and some clinical parameters, including tear film osmolality, 94 best clinical practices, 95 and immune cell and corneal sub-basal nerve abnormality by in vivo confocal study. 96 One study showed only a weakly positive correlation with subepithelial fibrosis and severe dry eye measured by using ICOS, although there is no significant correlation among subepithelial fibrosis, meibomian gland atrophy, and ICOS.…”

Section: Chronic Graft-versus-host Disease-related Dry Eyementioning

confidence: 73%

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Ogawa

2018

Invest. Ophthalmol. Vis. Sci.

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I have reviewed available literature on dry eye related to Sjögren's syndrome (SS), non-Sjögren's syndrome (non-SS), and graft-versus-host disease (GVHD) to examine aqueous tear deficient dry eye as a subtype of dry eye. This section will focus on clinical studies regarding those subtypes of dry eye. I searched the PubMed database from 1990-2017 for discussion of clinical features, diagnostic criteria, and risk factors of SS, non-SS, and GVHD-related dry eye. In addition, therapeutic options for each subtype of dry eye are described. Although the clinical presentations of SS and chronic graft-versus-host disease (cGVHD) are similar, ocular surface fibrotic changes are characteristic of ocular GVHD but not SS-or non-SS-related dry eye. Recently, diagnostic criteria for each disease have been proposed and include the American College of Rheumatology/European League Against Rheumatism (ACR-EULAR) for SS and the International Chronic Ocular GVHD consensus criteria. Although there has been gradual progress, there are currently no specific therapies and few approved treatment options for these intractable diseases, including SS and GVHD. As judged by the findings, these subtypes of dry eye are different clinical entities from simple dry eye. Therefore, novel therapies, specific to these subtypes of dry eye, may be required in the future.

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Section: Chronic Graft-versus-host Disease-related Dry Eyementioning

confidence: 73%

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Ogawa

2018

Invest. Ophthalmol. Vis. Sci.

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“…A recent study validated for the first time the ICCGVHD criteria, comparing them with best clinical practice (BCP), defined as ocular GVHD evaluation by highly trained single expert in ophthalmology on the basis of comprehensive clinical observation of the tear film and meibomian glands, among others [20]. There was slight overall agreement between BCP assessment and the ICCGVHD criteria for the diagnosis of chronic ocular GVHD.…”

Section: Discussionmentioning

confidence: 99%

Comparison among different diagnostic criteria for chronic ocular graft-versus-host disease applied with and without pre-transplant ophthalmological examination

Giannaccare

Versura

Bonifazi

et al. 2018

Eye

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“…A study comparing diagnostic utility between the 2005 NIH criteria and the ICOGCG criteria showed that the more stringent ICOGCG criteria better differentiated ocular GVHD [35]. Validation of ICOGCG diagnostic criteria, in comparison with diagnosis based on best clinical practice, showed good agreement and reproducibility, especially in more severe cases of ocular GVHD [54]. Further validation of the ICOGCG score, particularly for the applicability in clinical practice and as a response measure, is needed.…”

Section: Diagnosis Staging and Response Criteriamentioning

confidence: 99%

Ocular Graft-versus-Host Disease after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Inamoto¹,

Valdés-Sanz

Ogawa

et al. 2019

Biology of Blood and Marrow Transplantation

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A B S T R A C T Ocular graft-versus-host disease (GVHD) occurs in more than one-half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity that affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Recent updates in ocular GVHD regarding pathophysiology, preclinical models, risk factors, prevention, screening, diagnosis, response criteria, evaluation measures, and treatment are discussed. Ocular GVHD involves at least 3 biological processes: lacrimal gland dysfunction, meibomian gland dysfunction, and corneoconjunctival inflammation. Preclinical models have identified several novel pathogenic mechanisms, including the renin angiotensin system and endoplasmic reticulum stress signaling, which can be targeted by therapeutic agents. Numerous studies have identified reliable tests for establishing diagnosis and response assessment of ocular GVHD. The efficacy of systemic and topical treatment for ocular GVHD is summarized. It is important that all health professionals caring for HCT recipients have adequate knowledge of ocular GVHD to provide optimal care.

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Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD-Specific Metric

Abstract: The newly proposed ICCGVHD diagnostic criteria can be used reproducibly for the diagnosis and determination of severity of chronic ocular GVHD. However, larger prospective studies are needed to further validate it.

Cited by 37 publications

References 25 publications

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Comparison among different diagnostic criteria for chronic ocular graft-versus-host disease applied with and without pre-transplant ophthalmological examination

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