2005
DOI: 10.1093/chromsci/43.1.11
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Validation of Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry Method for the Determination of Mesocarb in Human Plasma and Urine

Abstract: Mesocarb metabolism in humans is the target of this investigation. A high-performance liquid chromatographic (LC) method with electrospray ionization (ESI)-ion trap mass spectrometric (MS) detection ion trap "SLIn the case of doping analysis, the reliable detection time for mesocarb (long-life dihydroxymesocarb metabolites of mesocarb) is approximately 10-11 days after the administration of the drug, which is a significant increase over the existing data. The detection of amphetamine in plasma and urine is mad… Show more

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Cited by 12 publications
(6 citation statements)
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“…Previous studies on the mesocarb and its metabolites identification reported the presence of parent mesocarb, two mono‐, three di‐ and two tri‐hydroxylated metabolites of mesocarb in human plasma and urine . A proposed scheme for the metabolic pathway of mesocarb in human and horse urine is illustrated in Figure .…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Previous studies on the mesocarb and its metabolites identification reported the presence of parent mesocarb, two mono‐, three di‐ and two tri‐hydroxylated metabolites of mesocarb in human plasma and urine . A proposed scheme for the metabolic pathway of mesocarb in human and horse urine is illustrated in Figure .…”
Section: Resultsmentioning
confidence: 99%
“…The characteristic ions at m/z 177, 119 and 91 were detected both for drug standard and post‐administration samples. The m/z 177 ion is characteristic fragment due to fragmentation of the sydnone ring . Extracted ion chromatograms for mesocarb of pre‐ and post‐administration samples are shown in Figure .…”
Section: Resultsmentioning
confidence: 99%
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“…However, it is almost unknown in Western countries and is not used in medicine. It has been shown to act as a dopamine reuptake inhibitor, antidepressant, and anticonvulsant [7,8].…”
Section: Sydnonesmentioning
confidence: 99%
“…MS/MS coupled with HPLC (high‐performance liquid chromatography) is the analytical technique of choice for most assays used during the discovery of new drugs (Appolonova, Dikunets, & Rodchenkov, 2008; Mesonzhnik et al, 2018; Moskaleva, Baranov, Mesonzhnik, & Appolonova, 2017; Shpak, Appolonova, & Semenov, 2005; Zherdev et al, 2009). Pharmacokinetic parameters of MEPACT [the liposomal‐encapsulated formulation of muramyl tripeptide phosphatidyl‐ethanolamine, mifamurtide (MTP‐PE), Takeda Pharmaceutical Company Ltd] in healthy adult volunteers with hepatic impairment were studied (Venkatakrishnan et al, 2012; Venkatakrishnan et al, 2014).…”
Section: Introductionmentioning
confidence: 99%