Validation of "Lung Age" Measured by Spirometry and Handy Electronic FEV1/FEV6 Meter in Pulmonary Diseases

Toda, Reiko; Hoshino, Tomoaki; Kawayama, Tomotaka; Imaoka, Haruki; Sakazaki, Yuki; Tsuda, Toru; Takada, Shiro; Kinoshita, Masaharu; Iwanaga, Tomoaki; Aizawa, Hisamichi

doi:10.2169/internalmedicine.48.1781

Cited by 48 publications

(43 citation statements)

References 30 publications

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“…p,0.05 was taken to represent statistical significance. The sensitivity and specificity of serum periostin levels for detecting IPF were analysed by using a receiver operating characteristic (ROC) curve generated by logistic regression as previously reported [18]. Statistical analysis was performed with JMP 7.0.1 (SAS Institute Japan, Tokyo, Japan).…”

Section: Discussionmentioning

confidence: 99%

Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias

et al. 2010

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Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) and cryptogenic organising pneumonia (COP). We investigated whether periostin, a matrix protein, could be used as a biomarker to assess histopathological types of IIPs.We performed immunohistochemical analyses in each histopathological type of IIP, examined serum levels of periostin in IIP patients and analysed the relationship between serum levels of periostin and the pulmonary functions in patients with idiopathic pulmonary fibrosis (IPF).Periostin was strongly expressed in lungs of UIP and fibrotic NSIP patients, whereas expression of periostin was weak in the lungs of cellular NSIP and COP patients, as well as in normal lungs. Serum levels of periostin in IPF were significantly higher than those of healthy subjects and COP patients. Furthermore, periostin levels in IPF patients were inversely correlated with their pulmonary functions.Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis.

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Section: Discussionmentioning

confidence: 99%

Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias

et al. 2010

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“…The concept of "spirometric-lung-age (SLA)" (the age of an average person who has, for example, FEV 1 equal to a subject) was developed in 1985 as a way of making spirometry data easier to understand (10) and also as a potential psychological tool to show smokers the apparent ageing of their lungs (11). However, the effect of these motivational interventions may be influenced by multiple factors including the differences in racial backgrounds and cultural practices (12), smoking cessation programs, and so on.…”

Section: Original Articlementioning

confidence: 99%

Effect of telling patients their “spirometric-lung-age” on smoking cessation in Japanese smokers

et al. 2017

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Background: Cigarette smoking remains a significant public health problem. However, current treatment programs have not yet succeeded in sufficiently reducing smoking rates. The study aimed to examine whether patients' recognition of "spirometric-lung-age (SLA)" estimated from spirometry data prompts smoking cessation. Methods: From December 2010 to September 2011, participating smokers were prospectively enrolled into the standardized smoking cessation program (Visits 1-5 for 12 weeks) and assigned single-blindly to either SLA assessment or control groups. The SLA group was informed of the estimated age of their lungs from spirometry analysis and given an opportunity to recognize the difference from their actual chronological age, whereas the control group was not. The primary calculation of outcome was the smoking quit rate on Visit 5, whereas the secondary end-point was the proportion of patients who remained abstinent 1 year later. Results: One hundred and twenty-six Japanese smokers (88 males) participated and were randomly assigned to the SLA group (n=52) or the control group (n=74). The smoking quit rate on Visit 5 was similar in the SLA assessment group and control group (59.6% vs. 41.9%; P=0.0700). However, the proportion of patients who remained abstinent 1 year later was similar in both groups (78.6% vs. 69.0%; P=0.5497). Multivariate logistic regression analysis after adjusting baseline characteristics demonstrated that telling patients their SLA, the use of varenicline, and age were significantly associated with smoking quit rate on Visit 5 whereas only age was associated with remaining abstinent 1 year later.Conclusions: Telling patients their SLA can become a useful tool prompting smoking cessation among Japanese smokers although other factors such as pharmacotherapy and age also influence the cessation of smoking.

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“…16,17 In Japan, lung age has also been investigated in relation to smoking status and body mass index 18 and in detecting pulmonary function abnormality in pulmonary diseases. 19 Despite mixed results, this flurry of recent publications indicates a renewed interest in the use of lung age to educate smokers about the deterioration of their lung function caused by smoking. International guidelines for smoking cessation state that primary care encounters provide good opportunities for smoking cessation advice and that tailored advice may be more effective, 20 and also that motivational counselling is of most use when it is relevant to the subject's risk status.…”

Section: Introductionmentioning

confidence: 99%

Exploring the need to update lung age equations

Newbury

Briggs

et al. 2010

Primary Care Respiratory Journal

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Aims: A renewed interest in lung age is evidenced by recent smoking cessation publications. This research compares the original Morris lung age equations (1985) with contemporary Australian lung age equations.Methods: Both lung age equations were applied to the spirometry results of two sub-groups (never-smokers n=340, and current smokers n=50) from an independent dataset. Means of both lung age estimates were compared to the mean of the chronological age of each group by paired Student's t-test.Results: The Morris lung age estimates were paradoxically lower (younger) than chronological age in both groups. The new Australian equation produced lung age estimates that were equivalent to chronological age in the never-smoker group and significantly higher (older) than chronological age in the current smoker group.Conclusions: These results strongly suggest that the Morris lung age equations are in need of review. The use of contemporary lung age equations may translate into greater success for smoking cessation programs. The new Australian equations seem to possess internal validity.

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Validation of "Lung Age" Measured by Spirometry and Handy Electronic FEV1/FEV6 Meter in Pulmonary Diseases

Abstract: Objective The concept of "lung age" is thought to be useful for understanding pulmonary function. In this study, we validated "lung age" to detect pulmonary function abnormalities in pulmonary diseases. Methods We used both spirometry and an electronic FEV1/FEV6 meter (FEV6 meter)

Cited by 48 publications

References 30 publications

Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias

Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias

Effect of telling patients their “spirometric-lung-age” on smoking cessation in Japanese smokers

Exploring the need to update lung age equations

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