2023
DOI: 10.3390/v15040930
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Validation of N Protein Antibodies to Diagnose Previous SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers: Use of Roche Elecsys® Immunoassay in the S Protein Vaccination Era

Abstract: The aim of this study was to validate the detection of anti-nucleocapsid protein (N protein) antibodies for the diagnosis of SARS-CoV-2 infection in light of the fact that most COVID-19 vaccines use the spike (S) protein as the antigen. Here, 3550 healthcare workers (HCWs) were enrolled from May 2020 (when no S protein vaccines were available). We defined SARS-CoV-2 infection if HCWs were found to be positive by RT-PCR or found to be positive in at least two different serological immunoassays. Serum samples fr… Show more

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“…Here, we cross-sectionally examined the impact of UDCA on SARS-CoV-2 infection in early 2023. The infection was defined based on medical interviews and SARS-CoV-2 immunoglobulin G against the nucleocapsid protein (IgG-N), which could detect the previous SARS-CoV-2 infection regardless of vaccination [5]. The cutoff value for IgG-N was set at 5 AU/mL [6], which identifies infections for approximately 1 year (unpublished data), covering the Omicron variant-dominant period in Japan.…”
Section: Dear Editormentioning
confidence: 99%
“…Here, we cross-sectionally examined the impact of UDCA on SARS-CoV-2 infection in early 2023. The infection was defined based on medical interviews and SARS-CoV-2 immunoglobulin G against the nucleocapsid protein (IgG-N), which could detect the previous SARS-CoV-2 infection regardless of vaccination [5]. The cutoff value for IgG-N was set at 5 AU/mL [6], which identifies infections for approximately 1 year (unpublished data), covering the Omicron variant-dominant period in Japan.…”
Section: Dear Editormentioning
confidence: 99%