Cross-section uncertainties of Pb and Bi isotopes could consequently affect the precision of nuclear design calculations of preliminary analyses, before the actual operation of upcoming ADS, since Pb and Bi are composed partly of coolant material (lead-bismuth eutectic: LBE) in ADS facilities. The main characteristics of LBE in ADS are recognized as follows: chemically inactive; high boiling point mechanically; excellent neutron economy caused by large scattering cross sections. From the viewpoint of neutronics, LBE exerts considerable impact on nuclear design parameters for numerical simulations of neutron interactions of Pb and Bi isotopes. As a suitable way of investigating cross-section uncertainties, sample reactivity worth measurements in critical states are considered effective with the use of reference and test materials in a zero-power state, such as a critical assembly, because integral parameter information on cross sections of test materials can be acquired experimentally. For the required experimental study on Pb and Bi nuclear data uncertainties, the sample reactivity worth experiments are carried out at the KUCA core by the substitution of reference (aluminum) for test (Pb or Bi) materials, and numerical simulations are performed with stochastic and deterministic calculation codes together with major nuclear data libraries.