2023
DOI: 10.3390/jcm12030795
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Validation of Noninvasive Assessment of Pulmonary Gas Exchange in Patients with Chronic Obstructive Pulmonary Disease during Initial Exposure to High Altitude

Abstract: Investigation of pulmonary gas exchange efficacy usually requires arterial blood gas analysis (aBGA) to determine arterial partial pressure of oxygen (mPaO2) and compute the Riley alveolar-to-arterial oxygen difference (A-aDO2); that is a demanding and invasive procedure. A noninvasive approach (AGM100), allowing the calculation of PaO2 (cPaO2) derived from pulse oximetry (SpO2), has been developed, but this has not been validated in a large cohort of chronic obstructive pulmonary disease (COPD) patients. Our … Show more

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Cited by 3 publications
(4 citation statements)
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“…The body's response to the hypoxaemic state, is characterized by an increase in minute ventilation that may drive to either an unrestrainable hypocapnia or hypercapnia (acidosis or alkalosis respectively), as the CO2 diffuses through tissues about 20 times faster than O2. Though the pathoanatomical and pathophysiological basis of ABG validity in assessing long-term systemic deficits still have to be fully clarify, the presence of progressive and damages remain the key point [5][6][7][8][9][10][11][12][13].…”
Section: Of 11mentioning
confidence: 99%
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“…The body's response to the hypoxaemic state, is characterized by an increase in minute ventilation that may drive to either an unrestrainable hypocapnia or hypercapnia (acidosis or alkalosis respectively), as the CO2 diffuses through tissues about 20 times faster than O2. Though the pathoanatomical and pathophysiological basis of ABG validity in assessing long-term systemic deficits still have to be fully clarify, the presence of progressive and damages remain the key point [5][6][7][8][9][10][11][12][13].…”
Section: Of 11mentioning
confidence: 99%
“…It widely accepted that metabolic acidosis works as the fertile soil of most physical, bone, nerves and mental degenerative diseases, the main traits of which are deficits in the cellular respiration mechanism. The degenerative patterns are observed with chronic inflammatory processes, and food intolerances, high toxic loading linked with active presence of opportunist micro-organism and heavy systemic dysbiosis [5][6][7][8][9][10][11][12][14][15][16][17][18].…”
Section: Extracellular Acidosis and The Immunity Clinical And Physiol...mentioning
confidence: 99%
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“…The AGM100 has been validated in healthy controls and in patients with stable cardiopulmonary disease and quantifies the oxygen deficit (OD), which is a surrogate for the alveolar arterial oxygen difference (A-aDO 2 ) colloquially known as the A-a gradient. Prior studies have used the AGM100 for a variety of cardiopulmonary conditions [14,15] and a variety of environmental extremes [16][17][18], but its role in acute illnesses, specifically COVID-19, is less clear.…”
Section: Introductionmentioning
confidence: 99%