Validation of ROPScore to predict retinopathy of prematurity among very low birth
            weight preterm infants in a southern Brazilian population

Cagliari, Patricia Zanotelli; Lucas, Vanessa Carvalho; Borba, Isabela Carolina; Leandro, Danieli Mayumi Kimura; Gascho, Carmem Luiza; Veras, Tiago Neves; Silva, Jean Carl; Filho, João Borges Fortes

doi:10.5935/0004-2749.20190093

Cited by 7 publications

(12 citation statements)

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“…The sensitivity of ROPScore was 73% which was lower than previous studies (95-100%) [6,23]. When the cutoff of ROPScore was decreased to 10.79, the sensitivity approached 100% and this cut off potentially would avoid screening in 16.5% of neonates and thus has clinical implication.…”

Section: Discussionmentioning

confidence: 53%

“…Secondary outcome was time from alarm to predict type 1 ROP by these algorithms to the time the neonates underwent treatment for the same. VOLUME 58 __ The reported specificity for CHOP-ROP was 51%, for ROPScore 57%, and for WINROP was 60% [6][7][8][9]18]. To detect a similar magnitude of difference (i.e.…”

Section: Chop-ropmentioning

confidence: 98%

“…However, due to their inability in providing 100% sensitivity (assuming gestation and weight risk factorbased screening criteria as standard), none of the algorithms have been able to replace existing protocols. These algorithms have shown high sensitivity and negative predictive value in many countries; however, they have not been widely validated in Indian settings [6][7][8]. Due to lack of sufficient literature in Indian settings, this study was planned with the aim to evaluate the diagnostic performance of all the three algorithms, namely WINROP (Weight, Insulin-like growth factor I, Neonatal ROP), CHOP-ROP (Children's Hospital of Philadelphia ROP) and ROPScore in predicting type 1 ROP in an Indian setting [9,10].…”

mentioning

confidence: 99%

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Diagnostic Accuracy of WINROP, CHOP-ROP and ROPScore in Detecting Type 1 Retinopathy of Prematurity

et al. 2021

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Background Algorithms for predicting retinopathy of prematurity (ROP) requiring treatment need to be validated in Indian settings to determine if the burden of screening can be reduced without compromising the sensitivity of existing gestation and weight-based cut offs. Objective To evaluate the performance of the available algorithms namely, WINROP (Weight, Insulin-like growth factor I, Neonatal ROP), CHOP-ROP (children’s Hospital of Philadelphia ROP) and ROPScore in predicting type 1 ROP and time from alarm to treatment by each algorithm. Study design Ambispective observational. Setting Tertiary care neonatal intensive care unit in India. Participants Neonates less than 32 weeks or less than 1500 g born between July, 2013 to June, 2019 (N=578), who underwent ROP screening. Primary outcome Sensitivity, specificity and time from alarm to treatment by each algorithm. Results The sensitivity and specificity of WINROP was 85% and 36%, for CHOP-ROP it was 54% and 71%, and for ROPScore it was 73% and 67%, respectively in detecting type 1 ROP. A total of 50/51 (98%) of neonates with type 1 ROP underwent treatment at median gestation of 9 weeks and median time from alarm to treatment by WINROP, CHOP-ROP and ROPScore was 7, 7 and 3 weeks, respectively. Conclusion WINROP, CHOP-ROP and ROPScore were not sensitive enough to replace the gestational age, weight and risk factor-based screening criteria for type 1 ROP.

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Section: Discussionmentioning

confidence: 53%

Section: Chop-ropmentioning

confidence: 98%

mentioning

confidence: 99%

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Diagnostic Accuracy of WINROP, CHOP-ROP and ROPScore in Detecting Type 1 Retinopathy of Prematurity

et al. 2021

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“…Portes et al (16) 151 Observational cohort study Schumann et al (17) 73 Retrospective cross-sectional study Shinsato et al (18) 70 Prospective study Tomé et al (19) 148 Retrospective cross-sectional observational study Almeida et al (20) 33 Retrospective cohort study Vieira et al (21) 267 Retrospective study Fortes Filho et al (22) 157 Prospective cohort study Gonçalves et al (23) 110 Longitudinal study Jorge et al (24) 232 Prospective cohort study Moinho et al (25) 343 Observational case-control study Silva et al (26) 172 Retrospective, analytical, case-control study Theis et al (27) 320 Cross-sectional and retrospective study Freitas (28) 602 Retrospective cohort study Horewicz et al (29) 183 Quantitative research approach with descriptive crosssectional design Martins (30) 280 Observational epidemiological study with case control design Pereira et al (31) 296 Retrospective cross-sectional study Fonseca et al (32) 323 Cohort study Lamy-Filho. (33) 1.961 Retrospective cohort study Malheiro et al (34) 375 Retrospective study Okamoto et al (35) 58 Cohort study Pastro et al (36) 181 Retrospective cohort study Xavier et al (37) 119 Cross-sectional, retrospective study Cagliari et al (38) 322 Retrospective study…”

Section: Resultsmentioning

confidence: 99%

“…(31,32) All articles addressed stages 1 and 3 ROP and only one article (22) did not include stage 2 ROP. As to stages 4 and 5, NBs with stage 4 ROP were investigated in ten articles (40%) (16,21,22,24,25,27,30,32,34,38) and NBs with stage 5 ROP in eight articles (32%). (16,21,22,27,30,31,32,38) With regard to the number of eyes analyzed and classified according to ROP severity, 4,698 did not have ROP, 820 had stage 1 disease and 404 had stage 2 disease (68.1%, 11.9% and 5.8% respectively).…”

Section: Resultsmentioning

confidence: 99%

Risk factors for retinopathy of prematurity: a systematic review

Cestari¹,

Lima²,

Rezende³

et al. 2021

Revista Brasileira De Oftalmologia

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Oral DHA supplementation and retinopathy of prematurity: the Joinville DHA Clinical Trial

Cagliari,

Hoeller,

Kanzler

et al. 2024

Br J Nutr

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Retinopathy of prematurity (ROP) is a leading cause of blindness in premature infants. The condition is associated with docosahexaenoic acid (DHA) deficiency. This study aimed to investigate the effect of DHA supplementation on the occurrence of ROP in infants receiving oral oil drops. It is part of the Joinville DHA study (JoiDHA Study), a non-parallel-group cohort study conducted from March 2020 to January 2023 at a public maternity hospital in Brazil. Infants born before 33 weeks of gestational age or with a birth weight ≤1,500 g were recruited. Among 155 infants, 81 did not receive and 74 received DHA supplementation until complete vascularization of the peripheral retina. There was a higher incidence of infants with ROP in the unsupplemented group (58·6%) compared to the DHA group (41·4%), but this difference was not significant (P=0·22). Unadjusted logistic regression analysis showed that patent ductus arteriosus and neonatal corticosteroids were significantly (P<0·05) associated with ROP in both groups. In the DHA group, surfactant use was also associated with ROP (P=0·003). After adjusting for important covariates, patent ductus arteriosus and neonatal corticosteroids continued to be significant for infants in the unsupplemented group (OR=3·99; P=0·022 and OR=5·64; P=0·019, respectively). In the DHA group, only surfactant use continued to be associated with ROP (OR=4·84; P=0·015). In summary, DHA supplementation was not associated with ROP. Further studies are necessary to better understand the relationship between DHA supplementation, ROP, and associated comorbidities.

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Validation of ROPScore to predict retinopathy of prematurity among very low birth weight preterm infants in a southern Brazilian population

Cited by 7 publications

References 0 publications

Diagnostic Accuracy of WINROP, CHOP-ROP and ROPScore in Detecting Type 1 Retinopathy of Prematurity

Diagnostic Accuracy of WINROP, CHOP-ROP and ROPScore in Detecting Type 1 Retinopathy of Prematurity

Risk factors for retinopathy of prematurity: a systematic review

Oral DHA supplementation and retinopathy of prematurity: the Joinville DHA Clinical Trial

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