Validation of Screening Models of Peptic Ulcer: A Review

Abstract

The stomach plays an important role in the digestion of the things we consume. This part of the body can withstand a wide range of harmful substances, such as hydrochloric acid, alcohol, refluxed bile salts, and other irritants. Upper abdominal pain may be a symptom of a gastrointestinal disorder known as Peptic Ulcer if you eat an unhealthy diet, smoke, drink too much alcohol, or take NSAIDs on a regular basis. You may also have a sedentary lifestyle. Today, gastric hyperacidity and gastroduodenal ulcers are very common problems all over the world. In this article, the author tries to give an overview of the in vivo and in vitro screening models that have been used in different laboratories and their validation during the past few decades to carry out such investigations, along with the underlying mechanisms of ulcer induction in each approach. The goal is to educate of the various experimental models available for conducting novel investigations to gain further knowledge in context to peptic ulcers.