GENis is an open source multi-tier information system developed to run a forensic DNA database at local, regional and national levels. 1 It was conceived as a highly customizable system, enforcing several security policies including: data encryption, double factor identification, structure of user's roles and permissions, system-wide secure log auditing, non-repudiation protocols and a blockchain-based option to reinforce genetic profile´s integrity. GENis is able to perform genetic profile queries of autosomal STR's and its design follows ENFSI 2 and ISFG 3 standards and recommendations. In this work, we present a summary of GENis architecture, the implemented matching rule definitions, and the Bayesian framework used to provide statistical significance of cold hits, that includes a new strategy to identify common contributors in mixture pairs.