Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents

Güngör, Neslihan; Saad, Rola; Janosky, Janine; Arslanian, Silva

doi:10.1016/j.jpeds.2003.09.045

Cited by 407 publications

(353 citation statements)

References 38 publications

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“…Insulin and C-peptide levels, and HOMA-IR were considered as parameters of insulin resistance. Insulin level and HOMA-IR correlate strongly with S i assessed by the frequently sampled IVGTT in young persons [18,19].…”

Section: Laboratory Analysesmentioning

confidence: 86%

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

et al. 2006

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Aims/hypothesis: An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not provided follow-up into adulthood. We studied the effects of (1) lower birthweight (as standard deviation score [SDS]) and infancy weight gain on insulin resistance in 19-year-olds born before 32 weeks of gestation, and (2) the interaction be-

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Section: Laboratory Analysesmentioning

confidence: 86%

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

et al. 2006

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“…22 MAP was used as it represents both systolic and diastolic blood pressure. A higher cMetS represents adverse metabolic profile.…”

Section: Metabolic Syndrome In Childrenmentioning

confidence: 99%

Efficacy of a continuous metabolic syndrome score in Indian children for detecting subclinical atherosclerotic risk

et al. 2011

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Objective: To evaluate the continuous metabolic syndrome score (cMetS) in Indian children and to investigate its relationship with the risk of carotid arterial stiffness. Methods: Data on weight, height, mean arterial pressure, serum lipids, insulin, glucose, carotid intima-media thickness and stiffness parameters, that is, pulse wave velocity (PWV), elasticity modulus (Ep), stiffness index (b) and arterial compliance (AC), were assessed in 236 children (6-17 years) from Pune city, India. cMetS was computed using standardized Z-scores for metabolic syndrome (MS) components. cMetS cutoff was obtained by receiver operating characteristic curve analysis across MS components. Results: cMetS was lowest (À3.6 ± 2.0) in normal children and highest (3.3 ± 2.4) in MS children. cMetS increased progressively with number of risk components. The cutoff of cMetS yielding maximal sensitivity (80%) and specificity (94%) for predicting the presence of MS was À0.8 (area under the curve ¼ 0.921 (95% CI: 0.877-0.964)). In children with cMetS above À0.8, average PWV (4.3±0.6 m s À1 ), b (3.8±1.2) and Ep (50.4±14.5 kPa) were significantly higher than the respective values (3.7 ± 0.5 m s À1 ; 3.4 ± 0.8; 37.0 ± 10.0 kPa) in children with cMetS below À0.8, whereas AC was lower (1.2 ± 0.5 mm 2 kPa À1 ) in children with cMetS above À0.8 as against AC (1.4±0.3 mm 2 kPa À1 ) in children with cMetS below À0.8 (Po0.05), demonstrating the risk of stiffness with increasing score. Pearson's correlation coefficients of cMetS with PWV (r ¼ 0.575), b (r ¼ 0.347), AC (r ¼ À0.267) and Ep (r ¼ 0.530) were statistically significant (Po0.01). Conclusion: Results demonstrate the usefulness of cMetS over individual MS components as a better tool for assessment of atherosclerotic risk in children.

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“…The intra-and interassay CV values were 3.7 and 5.1%, respectively. Insulin resistance was estimated by the homeostasis model assessment (HOMA), calculated as (insulin [μU/ml]×glucose [mmol/l])/22.5 [22].…”

Section: Laboratory Analysismentioning

confidence: 99%

Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents

Platat

Wagner

Klumpp³

et al. 2006

Diabetologia

103

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Aims/hypothesis Physical activity has beneficial effects on symptoms of the metabolic syndrome and low-grade inflammation in adults. These associations have rarely been studied in adolescents. Moreover, it has not been established whether they depend on adiposity, fat localisation and adipokines. Subjects, materials and methods We used cross-sectional data of 640 12-year-old adolescents participating in the Intervention Centred on Adolescents' Physical Activity and Sedentary Behaviour Study (ICAPS). Weight, height, body fat mass and WHR were measured. Metabolic syndrome components, two inflammatory markers (IL-6 and Creactive protein), plasma leptin, adiponectin and soluble TNF-α receptor 1 (sTNF-α R1) were determined. Insulin resistance was estimated by homeostasis model assessment (HOMA) and energy expenditure due to organised leisuretime physical activity (PAE) assessed by questionnaire. Results The metabolic syndrome was present in 5.8% of the adolescents. After adjustment for sex, sexual maturity and socio-economic status, a beneficial relationship between PAE and all metabolic syndrome features was found, but only the associations with HOMA and IL-6 were independent of body fat mass and WHR. Adjusted means from the lowest to the highest tertile of PAE were 1.99, 1.80 and 1.78 for HOMA (p=0.04), and 0.88, 0.69 and 0.70 pg/ml for IL-6 (p=0.02). PAE was inversely associated with leptin, independently of body fat mass and WHR (p<10 −2 ), but not with adiponectin or sTNF-α R1. Further adjustment for adipokines did not change the relationships of PAE with HOMA and IL-6. Conclusions/interpretation In adolescents, physical activity is inversely related to HOMA and IL-6, independently of adiposity and fat localisation. These relationships are not accounted for by adipokines.

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Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents

Cited by 407 publications

References 38 publications

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

Efficacy of a continuous metabolic syndrome score in Indian children for detecting subclinical atherosclerotic risk

Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents

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