Validation of the Canine Atopic Dermatitis Extent and Severity Index (<scp>CADESI</scp>)‐4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs

Olivry, Thierry; Saridomichelakis, M. N.; Nuttall, Tim; Bensignor, Emmanuel; Griffin, Craig E.; Hill, Peter

doi:10.1111/vde.12107

Cited by 157 publications

(221 citation statements)

References 13 publications

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“…Even though the QoL questionnaire has been validated and is applicable to all dermatological conditions, the pre‐question and interview were not validated. The CADESI‐04 score has been validated, but only for dogs with atopic dermatitis . Nevertheless, it was considered the best available option for this study.…”

Section: Discussionmentioning

confidence: 99%

Skin and ear health in a group of English bulldogs in Finland – a descriptive study with special reference to owner perceptions

Seppänen

Kaimio²,

Schildt³

et al. 2019

Veterinary Dermatology

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Background Dermatological conditions are common in English bulldogs (EBs). Hypothesis/Objectives This cross‐sectional study describes the dermatological health status of a group of EBs and compares the results with owner perceptions and its possible impact on quality of life (QoL). Computed tomographic (CT) findings of the ear canals were compared between EBs and mesaticephalic dogs. Animals Twenty‐seven EBs participating in a health study in Finland. Methods and materials A QoL questionnaire was completed for EBs with owner‐reported clinical signs referable to the skin or ear. Clinical evaluation included recording the Canine Atopic Dermatitis Extent and Severity Index, the Otitis Index Score, false paw pad grading and the presence of interdigital furunculosis. These were summed to form a total clinical score (TCS). The cross‐sectional surface areas of the horizontal ear canals were measured from CT images and compared with respective images of 14 mesaticephalic dogs collected from a patient database. Results All 27 EBs had abnormal findings on dermatological examination, but 37% of the owners had not recognized skin or ear signs. The median QoL score was 5.0 (range 0–12) and correlated with TCS (correlation coefficient = 0.507, P < 0.05). English bulldogs had narrower horizontal ear canals than mesaticephalic dogs (P < 0.001). Conclusions and clinical importance All EBs had abnormal dermatological findings that were unnoticed or considered to be of minor significance to the QoL by most owners. Narrow ear canals were common, possibly related to the brachycephalic conformation of the breed.

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Section: Discussionmentioning

confidence: 99%

Skin and ear health in a group of English bulldogs in Finland – a descriptive study with special reference to owner perceptions

Seppänen

Kaimio²,

Schildt³

et al. 2019

Veterinary Dermatology

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“…In particular, comparison of the median pruritus scores before and after treatment is preferred to using the number of dogs showing a 50% improvement as a primary outcome measure [21]. Apart from the VAS, there are severity scales to grade skin lesions in clinical trials, such as CADESI-04 [18]. However, these scales are more useful in long term studies [10].…”

Section: Discussionmentioning

confidence: 99%

“…This period was at least 14 days for topical glucocorticoids, oral glucocorticoids, and antihistamines, and at least 4 weeks for long-acting corticosteroids [1821]. During the withdrawal period, dogs were treated with 3% chlorhexidine shampoo (Douxo; Sogeval Laboratories, France; 1–2 times weekly) to prevent development of secondary infections.…”

Section: Methodsmentioning

confidence: 99%

Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

Hsiao¹,

Chen²,

Willemse

2016

J Vet Sci

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This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.

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“…Since 1997, objective lesion scores for canine atopic dermatitis (AD) have been developed and evaluated . The International Task Force on Canine AD [now the International Committee on Allergic Diseases of Animals (ICADA)] established the fourth version of the Canine Atopic Dermatitis Extent and Severity Index (CADESI‐4) in 2014 . The CADESI‐4 assesses erythema, lichenification, and alopecia/excoriations over 20 body regions on a 0–3 severity scale.…”

Section: Introductionmentioning

confidence: 99%

A pilot study to develop an objective clinical score for canine otitis externa

Nuttall

Bensignor²

2014

Veterinary Dermatology

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Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)‐4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs

Abstract: The CADESI-4 is simpler to use and quicker to administer than its previous version. The ICADA recommends the CADESI-4 instead of the CADESI-3 to score skin lesions of AD in dogs enrolled in clinical trials.

Cited by 157 publications

References 13 publications

Skin and ear health in a group of English bulldogs in Finland – a descriptive study with special reference to owner perceptions

Skin and ear health in a group of English bulldogs in Finland – a descriptive study with special reference to owner perceptions

Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

A pilot study to develop an objective clinical score for canine otitis externa

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