Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts

Avouac, Jérôme; Hecquet, Sophie; Thomas, Marion; Combier, Alice; Carvès, Sandrine; Allanore, Yannick

doi:10.1136/ard-2023-225272

Ann Rheum Dis

2024

DOI: 10.1136/ard-2023-225272

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Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts

Jérôme Avouac,

Sophie Hecquet,

Marion Thomas

et al.

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2024

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Verification of flare definition of rheumatoid arthritis based on SDAI and CDAI

Yoshii,

Sawada,

Chijiwa

2024

Int J of Rheum Dis

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A definition of "flare" in patients with rheumatoid arthritis (RA) was recently announced. 1 This definition uses the simplified disease activity index (SDAI) and clinical disease activity index (CDAI).The paper emphasizes its reliability as a material for determining withdrawal conditions in studies such as clinical trials and for an endpoint of the drug tapering process. Still, more importantly, flare can be determined immediately in front of the patient in a clinical setting.Before the definition, poor disease control was an indicator of transition to phase 2. However, the judgment relied on each institution or rheumatologist, 2,3 so the flare differed. After publication, French cohort studies reported that the definition helped identify the risk of poor disease control. 4 By defining flare, we can appropriately determine when to intervene with effective biological or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsD-MARDs) when moving to phase 2. This study evaluated whether the definition functions effectively as a decision to move to phase 2 or later using a real-world small cohort dataset.Japanese patients with RA who met the 2010 EULAR/ACR classification criteria 5 and followed up for more than three consecutive years from August 2010 to April 2020, following EULAR recommendations for RA since 2010 and every 3 years, were recruited in the study. 6 Patients who censored withdrawal by admission for reasons other than disease control worsening, such as severe infections and worsening of comorbidities, at death for any reasons, or temporally dropping out following up for any reasons by the date of 3 years from

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Verification of flare definition of rheumatoid arthritis based on SDAI and CDAI

Yoshii,

Sawada,

Chijiwa

2024

Int J of Rheum Dis

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Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts

Cited by 1 publication

References 4 publications

Verification of flare definition of rheumatoid arthritis based on SDAI and CDAI

Verification of flare definition of rheumatoid arthritis based on SDAI and CDAI

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