Validation of the Developed Zero-Order Infrared Spectrophotometry Method for Qualitative and Quantitative Analyses of Tranexamic Acid in Marketed Tablets

Nerdy, Nerdy; Margata, Linda; Sembiring, Bunga Mari; Ginting, Selamat; Putra, Effendy De Lux; Bakri, Tedy Kurniawan

doi:10.3390/molecules26226985

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…The newly developed ATR-IR spectrometric method was validated for the quantitative determination of sevoflurane by carrying out the stated validation tests in US pharmacopeia protocol and some reported scientific works. [ 19 20 ]…”

Section: Methodsmentioning

confidence: 99%

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Hasson

2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Sevoflurane, also called fluoromethyl ether, is an inhalation anesthetic agent used to initiate and maintain general anesthesia for adults and pediatric patients during surgical procedures. Several analytical methods have previously been applied to follow the properties and quality of sevoflurane, including mass spectrometry and gas chromatography methods. These methods are practically tedious and need sophisticated apparatus. In the present work, an attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectrometric method was used for the quantitative determination of sevoflurane which is characterized as a fast, accurate, and available technique for most pharmaceutical laboratories, besides the gas chromatographic method which is the most suitable for the detection of impurities. Sevoflurane is a liquid and it is applied directly on the glass top of the ATR-FTIR either as a concentrated solution or diluted with hexane as a diluent, which did not interfere with sample determination within the specified wavelength range of the IR spectrum, particularly the wavelength of the ethereal group at 1200 cm−1. This method can be applied to the identification test and quantitative assay of sevoflurane since it is validated for the precision, accuracy, reproducibility, and specificity in the analysis of sevoflurane as a pharmaceutical product. However, still, there is a need for a gas chromatographic method to detect the impurities and degradation products during the stability study of sevoflurane.

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Section: Methodsmentioning

confidence: 99%

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Hasson

2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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“…These methods are validated and used in routine analysis. These methods are also found to be green in nature (Nerdy et al, 2021;Sparén et al, 2015;Pelletier et al, 2012). Electrophoretic methods such as capillary electrophoresis (CE) can also be used to quantify TXA.…”

Section: Introductionmentioning

confidence: 99%

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

Singh,

Lokhande,

Kochrekar

2023

IJERR

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Tranexamic acid (TXA) is a widely used antifibrinolytic agent that is used to prevent and treat excessive bleeding. Current analytical methods for TXA are often time-consuming and require the use of toxic solvents. Raman spectroscopy has the ability to measure TXA because it is a fast and non-destructive analytical method. This research established and validated a green Raman spectroscopic test for TXA measurement. There was no need for harmful solvents because the technique relied on a basic aqueous solution of TXA. Results demonstrated that the technique was linear across the 0.7% to 13.0% concentration range. The method was also shown to be accurate, with results comparable to the orthogonal techniques. The green Raman spectroscopic assay method was applied to the quantification of TXA in pharmaceutical formulations. The results obtained were comparable to those obtained using reference methods. To quantify TXA quickly and accurately, one can use the green Raman spectroscopic test. Since no harmful chemicals are needed for the procedure, it is also eco-friendly. Method has the potential to be used in a variety of settings, including pharmaceutical quality control and research laboratories.

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Competitive effect and mechanism analysis of spectrophotometric detection of Ca2+ in metal cations-containing coal slurry water system

Zhang,

Min,

Liu

et al. 2024

Microchemical Journal

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Validation of the Developed Zero-Order Infrared Spectrophotometry Method for Qualitative and Quantitative Analyses of Tranexamic Acid in Marketed Tablets

Cited by 4 publications

References 45 publications

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

A Green Raman Spectroscopic Assay Method for The Quantification of Tranexamic Acid in Pharmaceutical Formulations

Competitive effect and mechanism analysis of spectrophotometric detection of Ca2+ in metal cations-containing coal slurry water system

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