“…In tumors, MDK can promote tumor cells differentiation, proliferation, anti-apoptosis, chemoresistance, transformation and epithelial-mesenchymal transition (EMT) [ 4 – 7 ]. High MDK protein expression has been reported in several cancer types and associated with the cancer progression, including gastric cancer [ 8 ], pancreatic cancer [ 9 ], lung cancer [ 10 ], breast cancer [ 11 ], colorectal carcinoma [ 12 ], esophageal cancer [ 13 ], hepatocellular carcinoma [ 14 ] and bladder cancer [ 15 ]. An important example, MDK is overexpressed in about 50% of pancreatic cancer patients, and participates in the tumor cells chemotherapy resistance through the Notch 2 signaling pathway [ 16 ].…”