Validation of the Estimation of Low-density Lipoprotein Cholesterol by the Modified Friedewald Equation in Ethnic Chinese Adults Living in Taiwan

Hsu, Sandy Huey-Jen; Chen, Ming-Fong; Chen, Duan‐Rung; Su, Ta‐Chen

doi:10.2169/internalmedicine.54.4308

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…The measurement was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), as previously described [ 36 ]. The serum levels of T-CHO, triglycerides, HDL-C, and LDL-C were measured using a homogeneous enzymatic method with a commercial kit (Denka Seiken) and were conducted on a Toshiba FR-200 automatic chemistry analyzer (Toshiba, Tokyo, Japan) [ 37 ]. The VLDL-C levels were determined by agarose gel electrophoresis, as previously described [ 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

“…The serum levels of T-CHO, triglycerides, HDL-C, and LDL-C were measured using a homogeneous enzymatic method with a commercial kit (Denka Seiken) and were conducted on a Toshiba FR-200 automatic chemistry analyzer (Toshiba, Tokyo, Japan) [ 37 ]. The VLDL-C levels were determined by agarose gel electrophoresis, as previously described [ 37 , 38 ]. The plasma sdLDL-C levels were determined using the method of sd-LDL-EX “SEIKEN” on a Toshiba FR-200 automatic chemistry analyzer (Toshiba, Tokyo, Japan), as previously described [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

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Association between Vitamin D Deficiency and High Serum Levels of Small Dense LDL in Middle-Aged Adults

Han

Hsu

2021

Biomedicines

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Recent studies suggested a potential link between vitamin D deficiency and cardiovascular risk factors, including dyslipidemia. This study aimed to investigate the association between serum 25(OH)D levels and atherogenic lipid profiles, specifically, that of small dense low-density lipoprotein-cholesterol (sdLDL-C). From 2009 to 2011, a total of 715 individuals aged 35–65 without evident cardiovascular disease (CVD) were enrolled. Their levels of serum 25(OH)D and lipid profiles were measured. Vitamin D deficiency was found to be more common in females, smokers, alcohol drinkers, individuals at a younger age, and those who do not exercise regularly. The analysis of lipid profiles revealed that high sdLDL-C levels were associated with low serum vitamin D levels and were more common among cigarette smokers; alcohol drinkers; individuals with hypertension; individuals with high BMI; and those with high levels of fasting blood glucose, triglycerides, LDL-C, and VLDL-C. The use of multivariate logistic regression verified a strong negative correlation between low vitamin D status (serum 25(OH)D < 15 ng/mL) and the three identified biomarkers of atherogenic dyslipidemia: high serum levels of sdLDL-C, triglycerides, and VLDL-C. This study provides strong evidence that vitamin D deficiency is associated with atherogenic dyslipidemia, and in particular, high sdLDL-C levels in middle-aged adults without CVD.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association between Vitamin D Deficiency and High Serum Levels of Small Dense LDL in Middle-Aged Adults

Han

Hsu

2021

Biomedicines

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“…Serum concentration of fasting blood glucose (FBG, mg/dL), triglyceride (TG, mg/dL), total cholesterol (TC, mg/dL), high-density lipoprotein cholesterol (HDL-C, mg/dL), low-density lipoprotein cholesterol (LDL-C, mg/dL), aspartate aminotransferase (AST, IU/L), and alanine aminotransferase (ALT, IU/L) were measured using an automatic analyzer (Hitachi 7600, Hitachi, Tokyo, Japan). To complement the missing data, LDL-C was calculated using the Friedewald equation, LDL-C (mg/dL) = TC (mg/dL) - HDL-C (mg/dL) - (TG [mg/dL]/5) in subjects with <400 mg/dL of TG [21]. …”

Section: Methodsmentioning

confidence: 99%

Selected Food Consumption Mediates the Association between Education Level and Metabolic Syndrome in Korean Adults

Kim

Kwak²,

Kim³

et al. 2017

Ann Nutr Metab

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Background/Aims: Low socioeconomic status (SES) is linked to higher incidence/mortality of cardiovascular disease, but emerging evidence inconsistently reported that education level, a proxy for SES, is related to cardiovascular risk and metabolic syndrome (MetS) in Koreans. Furthermore, limited information is available on whether dietary components would mediate the relationship between education level and cardiovascular risk. We hypothesized that selected food consumption mediates the association between education level and MetS prevalence. Methods: Data from the Korea National Health and Nutritional Examination Survey (2008-2011) were included in cross-sectional analyses (n = 11,029, 30-64 years). The possible mediating effect of selected food groups (fruits, raw vegetables, red meat, milk, and soft drinks) on the association between education level and MetS was tested using a multiple mediation model. Results: Education level was negatively associated with MetS prevalence. The association between lower education level and higher MetS prevalence was partially mediated by selected food consumption (lower intakes of fruit, red meat and milk; higher intakes of vegetable and soft drink) after adjusted for covariates. Gender also modified the association between education level and MetS prevalence that was more prominent in women than in men. Conclusions: Selected food consumption substantially contributes to the association between education level and MetS in Korean adults, especially among women.

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“…Serum levels of and triglyceride, high-density lipoprotein (HDL) and total cholesterol levels were measured by chemistry analyzer (FUJI DRI-CHEM 4000i). The low-density lipoprotein (LDL) was estimated by using Friedewald formula [LDL = (total cholesterol)-(HDL)-(triglyceride)/5] [25]. …”

Section: Methodsmentioning

confidence: 99%

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice

Dubey

et al. 2016

PLoS ONE

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Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio. These elevated markers were significantly mitigated following 8 weeks CmNo1 treatment. Moreover, the chronic hyperglycemia-induced pathological alteration in renal tissue were also ameliorated. Besides, immunohistochemical study demonstrated a substantial reduction in elevated levels of carboxymethyl lysine, an advanced glycation end product. Elevated collagenous deposition in DN group was also attenuated through CmNo1 administration. Moreover, the enhanced levels of transforming growth factor-β1, a fibrosis-inducing protein in glomerulus were also markedly dampened. Furthermore, auxiliary risk factors in DN like serum triglycerides and cholesterol were found to be increased but were decreased by CmNo1 treatment. Conclusively, the results suggests that CmNo1 exhibit potent and efficacious renoprotective action against hyperglycemia-induced DN.

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Validation of the Estimation of Low-density Lipoprotein Cholesterol by the Modified Friedewald Equation in Ethnic Chinese Adults Living in Taiwan

Cited by 8 publications

References 28 publications

Association between Vitamin D Deficiency and High Serum Levels of Small Dense LDL in Middle-Aged Adults

Association between Vitamin D Deficiency and High Serum Levels of Small Dense LDL in Middle-Aged Adults

Selected Food Consumption Mediates the Association between Education Level and Metabolic Syndrome in Korean Adults

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice

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