Validation of the French version of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)

Maubeuge, Nicolas; Deloire, Mathilde; Brochet, Bruno; Ehrlé, Nathalie; Charré-Morin, Julie; Saubusse, Aurore; Ruet, Aurélie

doi:10.1016/j.msard.2020.102692

Cited by 7 publications

(11 citation statements)

References 24 publications

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“…In the French validation study of the MACFIMS (Minimal Assessment of Cognitive Function in MS) battery, the frequency of cognitive impairment was twice as high in the SPMS group ( n = 46) than in the RRMS group ( n = 43). The two groups were not compared directly with each other but with distinct groups of control subjects matched to each of the groups by age, sex, and level of education [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

et al. 2022

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Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is mainly based on studies that compared the frequency and main characteristics of cognitive deficits in SPMS with other phenotypes. Methods: A bibliographic search was carried out using the PubMed database with the following keywords: multiple sclerosis, secondary-progressive, cognition. Results: Thirteen studies were initially selected that were published in English, reporting the neuropsychological data of a sample of at least 30 patients with SPMS, comparing them with patients with other phenotypes. Studies suggest that there is an association between the duration of the disease and the frequency and extent of the cognitive disorders. Studies also showed that the SP form is associated with an increased frequency of cognitive impairment and with an increased severity as compared to relapsing-remitting MS (RRMS). Compared to RRMS, progressive forms of MS are associated with more severe impairment in certain cognitive areas, such as episodic verbal memory, information processing speed, working memory, or verbal fluency. Two studies showed that cognitive performances decline overtime in SPMS. Conclusion: Cognitive disorders are more frequent and more severe in the SP form than in relapsing course of MS. The profile of cognitive impairment encountered in the SP form also appears to be different from those found in the other phenotypes.

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Section: Resultsmentioning

confidence: 99%

Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

et al. 2022

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“…The FLT is an assessment of episodic verbal memory, which was adapted from the CVLT. 7,10 For the BCCAMS, the test included five trials for learning a 16-word list (list A) corresponding to four semantic categories. For each trial, the subject is instructed to make a free reminder after the psychologist recalls the complete list.…”

Section: Methodsmentioning

confidence: 99%

“…The MACFIMS were described in detail previously. 2 The adapted MACFIMS battery, which was recently validated in France, 10 included the Paced Auditory Serial Addition Test (PASAT) with a 3.0-s interstimulus interval 14 (working memory and IPS), the SDMT 4 (IPS), the FLT (total learning and delayed recall), 7,10 the Brief Visuospatial Memory Test-Revised (BVMT-R; visual episodic memory, that is, total learning and delayed recall) (BVMT-DR), 6 the French adaptation of the Delis-Kaplan Executive Function System Sorting Test, 15 the "épreuve de classement de cartes de Champagne" (ECCC) developed by one of the researchers (NE) (total correct sorts and description score; previously described), 9 the Judgment of Line Orientation Test (JLOT) 16 (spatial orientation), and the Controlled Oral Word Association Test (COWAT). 16 The BICAMS is composed of the SDMT, the five learning trials of the FLT, and the first three learning trials of the BVMT-R. 3 All tests were administered in a single testing session in the following order: CSCT, CEVMT, CVLT, JLOT, CEVMT-DR, SDMT, CVLT DR, BVMT-R, PASAT 3 s, ECCC, BVMTR-DR, and COWAT.…”

Section: Methodsmentioning

confidence: 99%

“…The third test, the French learning test (FLT), consists of the learning trials of a verbal episodic memory test included in the French adaptation of the BICAMS and was not presented on a computer. 7,10 The main objective of the study was to validate the BCCAMS. The regression-based norms of the CEVMT and the three-test battery (BCCAMS) were established using a sample of healthy subjects (HS).…”

Section: Validation Of a Brief Computerized Cognitive Assessment In M...mentioning

confidence: 99%

“…Norms of the other individual tests have been previously published (FLT, ECCC, CSCT). 7,8,10 The methodology for regression-based norms is described previously. 7,10,22,23 The detailed method is presented as a Supplementary Material.…”

Section: Psychometric Properties Of the Cevmtmentioning

confidence: 99%

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Validation of a Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) and comparison with reference batteries

et al. 2021

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Background: The Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) is a short neuropsychological battery for persons with multiple sclerosis (PwMS). Objectives: The main objective of the study is to validate the BCCAMS. Methods: PwMS and healthy subjects (HS) were evaluated using the BCCAMS which include two computerized tests, the Computerized Speed Cognitive Test and the Computerized Episodic Visual Memory Test (CEVMT), a newly developed visuospatial memory test, and the French learning test. The Minimal Assessment of Cognitive Function in MS (MACFIMS), including the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) tests, was also administered. Regression-based norms of the BCCAMS were calculated in 276 HS. BCCAMS was compared with BICAMS and MACFIMS for detection of cognitive impairment (CI). Results: Out of 120 PwMS, CI was detected using the BCCAMS, BICAMS (one impaired test), and MACFIMS (two impaired tests) in 59.1%, 50%, and 37.9%, respectively. The BCCAMS produced the same predictive value as that of the BICAMS battery for detecting CI in the MACFIMS. Conclusion: This study validated the BCCAMS as a validated computerized short assessment for information processing speed and learning in MS.

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The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis

Wu,

Francis,

Lucien

et al. 2024

Neuropsychol Rev

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It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-remitting multiple sclerosis and are associated with adverse functional consequences. However, estimates of cognitive impairment (CIm) prevalence vary widely. This study aimed to determine the pooled prevalence of CIm among adults with RRMS and investigate moderators of prevalence rates. Following prospective registration (PROSPERO; CRD42021281815), electronic databases (Embase, Scopus, Medline, and PsycINFO) were searched from inception until March 2023. Eligible studies reported the prevalence of CIm among adults with RRMS, as determined through standardized neuropsychological testing and defined as evidence of reduced performance across at least two cognitive domains (e.g., processing speed, attention) relative to normative samples, healthy controls, or premorbid estimates. The electronic database search yielded 8695 unique records, of which 50 met selection criteria. The pooled prevalence of cognitive impairment was 32.5% (95% confidence interval 29.3–36.0%) across 5859 participants. Mean disease duration and age were significant predictors of cognitive impairment prevalence, with samples with longer disease durations and older age reporting higher prevalence rates. Studies which administered more extensive test batteries also reported significantly higher cognitive impairment prevalence. Approximately one third of adults with RRMS experience clinical levels of CIm. This finding supports the use of routine cognitive testing to enable early detection of CIm, and to identify individuals who may benefit from additional cognitive and functional support during treatment planning.

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Validation of the French version of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)

Cited by 7 publications

References 24 publications

Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

Validation of a Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) and comparison with reference batteries

The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis

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