Validation of the Glasgow Antipsychotic Side-Effect Scale (GASS) in Greece

Abstract

The aim of the present study was to evaluate the linguistic adaptation and psychometric validation into the Greek language of the GASS scale for the assessment of side effects in patients treated with second generation antipsychotic medication. The GASS scale takes 5 minutes to complete (21 items for men and women) and contains self-explanatory questions in everyday plain English while providing a structured systematic method of reviewing antipsychotic side effects. The translation and cultural adaptation of the questionnaire was performed according to international standards. Internal consistency using the Cronbach α coefficient and test-retest reliability using the intraclass correlation coefficient (ICC) was used to assess the reliability of the instrument. Patient's sample consisted of 80 participants with a mean age of 42.6 years. Internal consistency and intraclass correlation coefficient were adequate (Cronbach α = 0.79 and ICC = 0.96). The test-retest percent agreement for the aforementioned categories was 95.9. Agreement was satisfactory according to Kappa coefficient which was equal to 0.78 (p<0.001).The Greek validation of the GASS scale shows appropriate feasibility, reliability, and discriminative performance as a patient-reported outcome to be used for the assessment of the impact of side effects on patients with schizophrenia.

<p>Mediating Effect Of The Motivation For Medication Use On Disease Management And Medication Adherence Among Community-Dwelling Patients With Schizophrenia</p>

“…The 22-item GASS uses a 4-point Likert scale to measure the severity of the adverse effects of the antipsychotic medication, with higher scores indicating more frequent adverse events 30. The Cronbach α of GASS was 0.79,31 and the validity of GASS was significantly correlated with Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS)30 that had good reliability and validity 30,31…”

Urdu Translation and Adaptation of Glasgow Antipsychotic Side-Effect Scale (GASS)

“…On account of its utility and efficacy, GASS has been translated and validated in Greece. The internal consistency and interclass correlation coefficient were adequate (Cronbach α = .79 and .96 respectively), while the test -retest reliability was also high (Maria et al, 2014). Furthermore, GASS has also been translated and adapted in Arabic (AlRuthia et al, 2018), Italian (Rodilico et al, 2022) and Japenese (Kitagawa et al, 2020) and found to be an effective, reliable and a patient friendly tool.…”