2024
DOI: 10.1002/mus.28325
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Validation of the Histamine‐ and Heat‐Induced Axon‐Reflex Flare Response in a Nonselected Population of People With Type 1 Diabetes

Pernille Tind,
Anna Larsen,
Mette Krabsmark Borbjerg
et al.

Abstract: Introduction/AimsDiabetic peripheral neuropathy affects small nerve fibers early, but adequate evaluation has proven difficult. One method for functional assessment of small nerve fiber function is the axon‐reflex flare (ARF) response. This study aimed to 1) validate the histamine‐induced ARF response in a nonselected population with diabetes, 2) compare the response to that induced by local heating, and 3) compare both methods to an established method (quantitative sensory testing) in a nonselected population… Show more

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