Validation of the Korean Addenbrooke's Cognitive Examination for Diagnosing Alzheimer's Dementia and Mild Cognitive Impairment in the Korean Elderly

Abstract

The Addenbrooke's Cognitive Examination (ACE) is a valid dementia-screening test that is a simple and effective instrument. We aimed to assess the diagnostic accuracy of the Korean version of the ACE (K-ACE) in a Korean population. A total of 115 subjects (50 with Alzheimer's dementia [AD], 26 with mild cognitive impairment [MCI], and 39 controls) who visited the Neurology Outpatient Clinic of Seoul Medical Center were included. The ACE was translated and modified to create the K-ACE. The sensitivity, specificity, area under the curve, reliability, and Verbal-Language/Orientation-Memory ratio were evaluated. The receiver-operating characteristic (ROC) curve was used to determine the optimal cutoff score in screening for dementia. The ROC curves showed the superiority of the K-ACE over the Korean Mini-Mental Status Examination in the diagnosis of AD and MCI. The optimal cutoff of the K-ACE for the identification of AD was 68/69, which had a sensitivity of 90% and a specificity of 84%. The K-ACE is a short, reliable, and valid neuropsychological test battery used to screen for dementia in the Korean elderly.

Usefulness of medial temporal lobe atrophy visual rating scale in detecting Alzheimer′s disease: Preliminary study

“…The K-ACE, which has higher specificity and sensitivity than those of the K-MMSE, was additionally used. [5]…”

“…[4] To overcome the disadvantages of the MMSE, ACE in which the evaluation of memory, language and visuospatial and verbal fluency are added to the MMSE has been developed and used in many countries including Korea. [5]…”

A review of amnestic MCI screening in east/southeast Asian older adults with low education: implications for early informant-clinician collaboration

“…First, not many researchers have designed or implemented studies on MCI for participants with low education. In some cases, those with lower education (less than 4 years) were excluded (Zhao et al , ), or were not included in the studies (Fujiwara et al , ; Hoe et al , ; Malmstrom et al , ; Yamao et al , ). Second, while it is intuitively important to involve informants whenever possible, it did not seem to be a common practice; and most evident in research that used only cognitive tests for identifying MCI (Lee et al , ; Lu et al , ; Yu et al , ).…”