Validation of the multiple sclerosis diagnosis in the Norwegian Patient Registry

Benjaminsen, Espen; Myhr, Kjell–Morten; Grytten, Nina; Alstadhaug, Karl Bjørnar

doi:10.1002/brb3.1422

Cited by 13 publications

(14 citation statements)

References 10 publications

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“…The MS diagnosis in NPR has previously been validated, with a sensitivity of 97% and positive predictive value 0.92. 16 MS diagnoses registered in NPR, but not in the MSR, were validated with information from hospital records using the 2017 diagnostic criteria for MS. 17 …”

Section: Methodsmentioning

confidence: 99%

Perinatal Depression and Anxiety in Women With Multiple Sclerosis

et al. 2021

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ObjectiveTo assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS).Methods114,629 pregnant women were included in the Norwegian Mother, Father and Child Cohort study 1999–2008. We assessed depression and anxiety by questionnaires during and after pregnancy. Women with MS were identified from national health registries and hospital records and grouped into 1) MS diagnosed before pregnancy (n = 140), MS diagnosed after pregnancy with 2) symptom onset before pregnancy (n = 98) and 3) symptom onset after pregnancy (n = 308). Thirty-five women were diagnosed with MS in the postpartum period. The reference group (n = 111,627) consisted of women without MS.ResultsWomen with MS diagnosed before pregnancy had an adjusted odds ratio of 2.0 (95% confidence interval 1.2–3.1) for depression in the third trimester. Risk factors were adverse socioeconomic factors, history of psychiatric disease and physical/sexual abuse. The risk of anxiety was not increased. Women diagnosed with MS in the postpartum period had especially high risk of postpartum depression. Women with MS symptom onset within 5 years after pregnancy had increased risk of both depression and anxiety during pregnancy, whereas women with more than 5 years until symptom onset did not.ConclusionWomen diagnosed with MS have increased risk of perinatal depression. Women with MS symptom onset within 5 years after pregnancy have increased risk of both depression and anxiety during pregnancy.

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Section: Methodsmentioning

confidence: 99%

Perinatal Depression and Anxiety in Women With Multiple Sclerosis

et al. 2021

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“…Diagnosis of MS is a prolonged and challenging process and some patients could be misdiagnosed [26]. However, a recent validation study on individuals residing in Nordland County in Norway and registered with MS in NPR examined the medical record of these individuals and reported that 91.5% of patients had a confirmed MS diagnosis [27]. We believe that our inclusion criteria for MS patients (patients with at least two registered diagnoses in specialist care or combination of information on diagnoses in specialist care with information on use of MS medications) provided a highly reliable identification of MS patients.…”

Section: Strengths and Weaknessesmentioning

confidence: 99%

Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway

et al. 2019

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Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. We conducted a populationbased registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The entire Norwegian population in the years 2008-2014 was defined as our study population (N = 5,219,296). Information on MS diagnosis, influenza infection and vaccination were provided by Norwegian national registries. The self-controlled case series method was used to estimate incidence rate ratios (IRRs) with 95% confidence intervals (95% CI) in defined risk periods. 6755 MS patients were identified during the study period. Average age at first registration of an MS diagnosis was 51.8 years among men and 49.9 years among females (66.9%). The IRR for emergency hospitalization among MS patients the first week after an influenza diagnosis was 3.4 (95% CI 2.4-4.8). The IRR was 5.6 (95% CI 2.7-11.3) after pandemic influenza, and 4.8 (95% CI 3.1-7.4) after seasonal influenza. Pandemic vaccination did not influence risk of hospitalization [IRR within the first week: 0.7 (95% CI 0.5-1.0)]. Among MS patients, influenza infection was associated with increased risk for acute hospitalization while no increased risk was observed after pandemic vaccination. Influenza vaccination could prevent worsening of MS-related symptoms as well as risk of hospitalization.

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“…To assess the completeness of the cohort, we will link data from the Norwegian Patient Registry and compare the number of incident patients in this registry within the corresponding geographical area and inclusion years, with the number of included patients. Validation of correct diagnoses in the Norwegian Patient Registry has been performed with other diagnoses [21], but not within IBD. However, a Swedish study found high validity of IBD diagnoses within the Swedish Patient Registry [22].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway

Kristensen

Opheim

Perminow

et al. 2021

Scandinavian Journal of Gastroenterology

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Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion:We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

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Validation of the multiple sclerosis diagnosis in the Norwegian Patient Registry

Cited by 13 publications

References 10 publications

Perinatal Depression and Anxiety in Women With Multiple Sclerosis

Perinatal Depression and Anxiety in Women With Multiple Sclerosis

Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway

Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway

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