Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study

Leteurtre, Stéphane; Martinot, A.; Duhamel, Alain; Proulx, François; Grandbastien, Bruno; Cotting, Jacques; Gottesman, Ronald; Joffe, Ari R.; Pfenninger, J.; Hubert, Philippe; Lacroix, Jacques; Leclerc, F.

doi:10.1016/s0140-6736(03)13908-6

Cited by 642 publications

(464 citation statements)

References 31 publications

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“…The presence of new or progressive multiorgan dysfunction syndrome (MODS) was measured for 7 days following severe sepsis recognition according to previously published criteria (20,33). For severity of illness, the Pediatric Index of Mortality (PIM)-3 score (34) was calculated at PICU admission, and the Pediatric Logistic Organ Dysfunction score (35) was collected on the study day. To facilitate consistent and accurate data collection, we used separate pilot and training phases, embedded quality checks within the electronic case report form, and secondarily validated missing or outlying data values (see Table E1 in the online supplement).…”

Section: Data Collectionmentioning

confidence: 99%

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Weiss

Fitzgerald

Pappachan

et al. 2015

Am J Respir Crit Care Med

846

625

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Rationale: Limited data exist about the international burden of severe sepsis in critically ill children.Objectives: To characterize the global prevalence, therapies, and outcomes of severe sepsis in pediatric intensive care units to better inform interventional trials.Methods: A point prevalence study was conducted on 5 days throughout 2013-2014 at 128 sites in 26 countries. Patients younger than 18 years of age with severe sepsis as defined by consensus criteria were included. Outcomes were severe sepsis point prevalence, therapies used, new or progressive multiorgan dysfunction, ventilator-and vasoactive-free days at Day 28, functional status, and mortality.Measurements and Main Results: Of 6,925 patients screened, 569 had severe sepsis (prevalence, 8.2%; 95% confidence interval, 7.6-8.9%). The patients' median age was 3.0 (interquartile range [IQR], 0.7-11.0) years. The most frequent sites of infection were respiratory (40%) and bloodstream (19%). Common therapies included mechanical ventilation (74% of patients), vasoactive infusions (55%), and corticosteroids (45%). Hospital mortality was 25% and did not differ by age or between developed and resourcelimited countries. Median ventilator-free days were 16 (IQR, 0-25), and vasoactive-free days were 23 (IQR,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Sixty-seven percent of patients had multiorgan dysfunction at sepsis recognition, with 30% subsequently developing new or progressive multiorgan dysfunction. Among survivors, 17% developed at least moderate disability. Sample sizes needed to detect a 5-10% absolute risk reduction in outcomes within interventional trials are estimated between 165 and 1,437 patients per group.Conclusions: Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbidity, and mortality rates similar to those reported in critically ill adult populations. International clinical trials targeting children with severe sepsis are warranted.

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Section: Data Collectionmentioning

confidence: 99%

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Weiss

Fitzgerald

Pappachan

et al. 2015

Am J Respir Crit Care Med

846

625

View full text Add to dashboard Cite

show abstract

“…Patients were diagnosed as having severe sepsis, defined as suspected or documented infection with the presence of systemic inflammation and signs of acute organ dysfunction using the Organ Failure Index (OFI), 9 the Pediatric Logistic Organ Dysfunction Score (PELOD) 10 and the Pediatric Risk of Mortality Score (PRISM).…”

Section: Design and Methodsmentioning

confidence: 99%

Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis

Nguyen¹,

Liu²,

Liu³

et al. 2007

Haematologica

133

108

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“…Two scores have been proposed for critically ill children: the Pediatric Logistic Organ Dysfunction (PELOD) score and the Pediatric Multiple Organ Dysfunction Score (P-MODS). [8][9][10] These scores quantify organ dysfunction precisely and can be used as indicators of the severity of illness throughout the clinical course. They can also be used as baseline and outcome measures in clinical studies conducted in ICUs 11,12 and pediatric ICUs (PICUs).…”

mentioning

confidence: 99%

“…13 The PELOD score calculated with data collected over the entire PICU stay has been validated (using the most abnormal value of each variable during the entire PICU stay). 10 However, the PELOD score over the entire PICU stay cannot be calculated before discharge from the unit; therefore, it cannot be used to characterize and follow the severity of organ dysfunction on a daily basis. Measurements repeated daily may provide more useful information.…”

mentioning

confidence: 99%

Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children

Leteurtre

Duhamel²,

Grandbastien³

et al. 2010

Canadian Medical Association Journal

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Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study

Cited by 642 publications

References 31 publications

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis

Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children

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