Validation of the paracetamol absorption test for measuring gastric tube emptying in esophagectomized patients versus gold standard scintigraphy

Djerf, Pauline; Brundin, Martin; Bajk, Marika; Smedh, Ulrika

doi:10.3109/00365521.2015.1041151

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…While scintigraphy is the gold standard for measuring gastric emptying, it can provide inconsistent results because of the lack of standardized procedures 41 . By contrast, the paracetamol absorption method is able to provide a similar degree of accuracy to scintigraphy, is widely used and therefore comparable across trials, and is inexpensive 42,43 . Finally, the proportion of female subjects enrolled in the trial was low (13.3%), and all of the participants were White, which could have affected the generalizability of the results as the trial population may not have been representative of a general T2D population.…”

Section: Discussionmentioning

confidence: 99%

Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes

Dahl

Brooks

Almazedi

et al. 2021

Diabetes Obesity Metabolism

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Aim: To assess the effects of oral semaglutide on postprandial glucose and lipid metabolism, and gastric emptying, in subjects with type 2 diabetes (T2D).Materials and Methods: In this randomized, double-blind, single-centre, crossover trial, subjects with T2D received once-daily oral semaglutide (escalated to 14 mg) followed by placebo, or vice versa, over two consecutive 12-week periods. Glucose and lipid metabolism, and gastric emptying (paracetamol absorption) were assessed before and after two types of standardized meals (standard and/or fat-rich) at the end of each treatment period. The primary endpoint was area under the glucose 0-5-h curve (AUC 0-5h ) after the standard breakfast.Results: Fifteen subjects were enrolled (mean age 58.2 years, HbA1c 6.9%, body weight 93.9 kg, diabetes duration 3.1 years; 13 [86.7%] males). Fasting concentrations of glucose were significantly lower, and C-peptide significantly greater, with oral semaglutide versus placebo. Postprandial glucose (AUC 0-5h ) was significantly lower with oral semaglutide versus placebo (estimated treatment ratio, 0.71; 95% CI, 0.63, 0.81; p < .0001); glucose incremental AUC (iAUC 0-5h/5h ) and glucagon AUC 0-5h were also significantly reduced, with similar results after the fat-rich breakfast. Fasting concentrations of triglycerides, very low-density lipoprotein (VLDL) and apolipoprotein B48 (ApoB48) were significantly lower with oral semaglutide versus placebo. AUC 0-8h for triglycerides, VLDL and ApoB48, and triglycerides iAUC 0-8h/8h , were significantly reduced after oral semaglutide versus placebo. During the first postprandial hour, gastric emptying was delayed (a 31% decrease in paracetamol AUC 0-1h ) with oral semaglutide versus placebo. One serious adverse event (acute myocardial infarction) occurred during oral semaglutide treatment. Conclusion:Oral semaglutide significantly improved fasting and postprandial glucose and lipid metabolism, and delayed gastric emptying.

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Section: Discussionmentioning

confidence: 99%

Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes

Dahl

Brooks

Almazedi

et al. 2021

Diabetes Obesity Metabolism

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show abstract

“…Patients received a semisolid meal labeled with 40 MBq of 99mTc-Nanocoll that even contained paracetamol 20 mg/kg patient weight. Paracetamol emptying test had a good concordance to the 25% and 50% gastric conduit emptying rate of the labeled meal according to scintigraphy (35).…”

Section: Symptoms Of Dgcementioning

confidence: 74%

“…Other factors that may affect the optimal passing time of food, are the level of anastomosis, anastomotic technique, size of the gastric conduit (31), and the topographic pathway of the conduit (32). Peristaltic movement of the gastric conduit has been shown, in general, to improve with time after surgery (30,(33)(34)(35). Other factors related to the postoperative phase, such as post-surgical bowel paralysis, patient mobilization after surgery and onset of per oral diet intake, may also affect early postoperative gastric conduit emptying.…”

Section: Pathophysiology Of Dgcementioning

confidence: 99%

Delayed emptying of the gastric conduit after esophagectomy

Konradsson¹,

Nilsson²

2019

J. Thorac. Dis

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With increasing survival after esophagectomy for cancer, a growing number of individuals living with the functional results of a surgically altered anatomy calls for attention to the effects of delayed gastric conduit emptying (DGCE) on health-related quality of life and nutritional impairment. We here give an overview of the currently available literature on DGCE, in terms of epidemiology, pathophysiology, diagnostics, prevention and treatment. Attention is given to controversies in the current literature and obstacles related to general applicability of study results, as well as knowledge gaps that may be the focus for future research initiatives. Finally, we propose that measures are taken to reach international expert agreement regarding diagnostic criteria and a symptom grading tool for DGCE, and that functional radiological methods are established for the diagnosis and severity grading of DGCE.

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Surgical Management of Esophageal Cancer Complications

Ozel,

Yardimci

2024

Risk Factors and Therapy of Esophagus Cancer

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Validation of the paracetamol absorption test for measuring gastric tube emptying in esophagectomized patients versus gold standard scintigraphy

Cited by 6 publications

References 34 publications

Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes

Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes

Delayed emptying of the gastric conduit after esophagectomy

Surgical Management of Esophageal Cancer Complications

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