Validation of the PCR string test (Entero-test) in the diagnosis of Helicobacter pylori gastritis

Lynch, S M.; Nowak, TV; J, Nowak; Konicek, Frank J.; Ghazanfari, K; Olivera, Aníbal Alarcón

doi:10.1016/s0016-5085(98)80846-9

Cited by 1 publication

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“…Currently, the recovery of H pylori organisms requires invasive techniques, primarily endoscopy and biopsy. Enterical string tests have been used for many years to obtain upper gastrointestinal fluid to aid in the assessment of gastric pH, bile salts and duodenal parasitic infections (26,27). This methodology has also been used to recover viable H pylori from the gastric mucus layer (26,27).…”

Section: String Tests Backgroundmentioning

confidence: 99%

“…The recovery of organisms can provide important information about strain type and the presence of antibiotic resistance. Methodology: One end of a highly adsorbent polymeric string is taped to the patient's cheek, and the remainder of the string is swallowed in a gelatin-coated capsule (26,27). The string remains in the stomach for 30 to 60 mins and is then removed manually.…”

Section: String Tests Backgroundmentioning

confidence: 99%

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Novel Diagnostic Tests to DetectHelicobacter pyloriInfection: A Pediatric Perspective

1999

Canadian Journal of Gastroenterology

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Helicobacter pylori is one of the most common bacterial infections in humans, and has been found in differing rates in persons of all age groups, nationalities and socioeconomic classes (1). Because the role of H pylori in human disease continues to be explored, there is an increased need for rapid, reliable and inexpensive diagnostic tests (2,3). The most commonly used standard tests are listed in Table 1. To date, the only test that can detect infection and disease activity is endoscopy with biopsy, which is invasive and expensive.Five recently developed tests that offer potential advantages because they are less invasive or permit easier acquisition of samples are assessed. These tests are whole blood, saliva and urine assays that measure systemic antibody response to H pylori, stool tests that measure H pylori antigens and string tests that use methodology less invasive than upper gastrointestinal endoscopy to recover H pylori organisms.The tests are compared with current standard tests and criteria for optimal tests. The criteria are non-or minimally invasive nature; high sensitivity, specificity, and positive and negative predictive values in diagnosing infection and assessing disease activity and effectiveness of therapy; convenience, including ease of acquisition of samples and rapid determination of results; and low cost. WHOLE BLOOD ANTIBODY TESTS Background:Whole blood antibody tests are based on the fact that systemic antibodies to H pylori are found in whole blood, making testing possible in a primary care setting (2-9). Whole blood tests have several important potential advantages compared with standard serological tests; the samples are easier to obtain, testing can be done in an office setting and the results can be available within 10 mins. In addition, the cost is projected to be less than that for the standard serological tests. CANADIAN HELICOBACTER CONSENSUS CONFERENCE ON PEDIATRIC ISSUES

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