The COVID-19 pandemic recently swept the globe, and quarantine sadly compelled most businesses and employees to adapt to the sudden change. Because of this, the employee may face psychological risks like a change in lifestyle, tiredness, burnout, and a drop in job satisfaction. Establishing how each aspect is associated with the job satisfaction of supply chain workers in the Philippines is the main topic of this study. Purposive sampling via an online survey is the non-probability sample method used in this investigation. The target respondents are the logistics company’s employees. Google Forms were used to deliver the self-administered online survey questionnaire. The SEM model was assessed using the hypothesis test’s beta coefficient and R2 findings. The model was proven sufficient to explain or forecast the employee’s loyalty to the organization, stress at work, and job satisfaction. Results of the study revealed that organizational commitment (β = 0.716; p-value < 0.001) had the highest positive association with workers’ job satisfaction, while work stress proved to have a negative association with job satisfaction (β = −0.166; p-value = 0.039). Similarly, job characteristics (β = 0.684; p-value < 0.001) and job involvement (β = 0.189; p-value = 0.009) were also proved to have a strong positive association with organizational commitment, which in turn influences job satisfaction. Finally, lifestyle behavior was found to have a positive association with work stress (β = 0.467; p-value < 0.001) and job burnout (β = 0.369; p-value = 0.001), negatively influencing job satisfaction. As a result, this study can offer supply-chain company personnel more information on the effect of organization commitment, lifestyle behavior, work stress, and job burnout on job satisfaction, which is a key component of job sustainability. Companies must ensure that employees are treated well and meet their demands to promote a sustainable workplace.