Validation of the Spanish version of Addenbrooke's Cognitive Examination III for diagnosing dementia

An Investigation of the Utility of the Addenbrooke's Cognitive Examination III in the Early Detection of Dementia in Memory Clinic Patients Aged over 75 Years

“…mild cognitive impairment (MCI), mood disorder etc. This represents a closer analogue to the clinical task in day-to-day practice than the case-control methodology used in the above validations [1,5]. On this basis, such studies should, as others have noted [6], explore whether the published cut-offs require revision to optimise diagnostic accuracy in clinical practice.…”

“…Sensitivity and specificity for differentiating early-onset dementia patients from healthy controls are comparable using the same cut-offs (1.0 and 0.96 for a score of 88/100; 0.93 and 1.0 for 82/100), and total ACE-R and ACE-III scores are significantly correlated (r p = 0.99, p < 0.01). The initial validation of a Spanish version of the ACE-III [5] also found high levels of accuracy in distinguishing healthy controls from patients with dementia, but with a lower sensitivity and specificity (0.83 and 0.80) at an optimal cut-off of 65.5. …”

“…Lower optimal ACE-R cut-off scores have also been identified for lower versus higher educated participants [12,17] and older versus younger participants [18,19]. Validation of the Spanish ACE-III [5] found a similar pattern of correlations between total scores and age and education, and lower optimal cut-off scores for those with less versus more education.…”

Screening for cognitive and behavioural impairment in amyotrophic lateral sclerosis: Frequency of abnormality and effect on survival

“…Therefore a variety of simple tools have been used to screen for cognitive impairment in ALS. These include Addenbrooke's cognitive examination-III (ACE-III), an updated version of the ACE-R [5][6][7][8], the Frontal assessment battery (FAB) [9][10][11], the Edinburgh cognitive and behavioral ALS screen (ECAS), which includes tests of social cognition, [12][13][14][15][16] and the ALS cognitive behavioral screen (ALS CBS) [17]. Table 1 shows the elements tested in the different tools.…”

Clinical and laboratory features of ALS

“…Therefore a variety of simple tools have been used to screen for cognitive impairment in ALS. These include ACE-III, an updated version of the ACE-R [83,[199][200][201] , FAB [84,202,203] , ECAS, which includes tests of social cognition [85,[204][205][206][207] and ALS CBS [86] . Table 5 shows the elements tested in the different tools.…”